ArticleEvidence-based complementary and alternative medicine : eCAM2013
Antinociceptive and anti-inflammatory effects of orally administrated denatured naja naja atra venom on murine rheumatoid arthritis models.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
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- Review
- Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Cobrotoxin from Naja naja atra Venom Ameliorates Adriamycin Nephropathy in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress.BMC complementary and alternative medicine · 2014Article
- Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Naja naja atra Venom Protects against Manifestations of Systemic Lupus Erythematosus in MRL/lpr Mice.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Differential Effects of Naja naja atra Venom on Immune Activity.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the antinociceptive and anti-inflammatory activities of the denatured Naja Naja atra venom (NNAV) in rheumatoid arthritis-associated models, the denatured NNAV (heat treated; 30, 90, 270 μ g/kg), the native NNAV (untreated with heat; 90 μ g/kg), and Tripterygium wilfordii polyglycoside (TWP, 15 mg/kg) were administrated orally either prophylactically or therapeutically. We measured time of licking the affected paw in formaldehyde-induced inflammatory model, paw volume in egg-white-induced inflammation, and granuloma weight in formalin-soaked filter paper-induced granuloma. For adjuvant-induced arthritis (AIA) rats, paw edema, mechanical withdrawal threshold, serum levels of TNF- α and IL-10, and histopathological changes of the affected paw were assessed. We found that the denatured NNAV (90, 270 μ g/kg) significantly reduced time of licking paw, paw volume, and granuloma weight in above inflammatory models and also attenuated paw edema, mechanical hyperalgesia, and histopathology changes in AIA rats. Additionally, the increase in serum TNF- α and the decrease in serum IL-10 in AIA rats were reversed by the denatured NNAV. Although the native NNAV and TWP rendered the similar pharmacological actions on the above four models with less potency than that of the denatured NNAV, these findings demonstrate that oral administration of the denatured NNAV produces antinociceptive and anti-inflammatory activities on rheumatoid arthritis.
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Registered trials
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