Trial reportSleep2013
Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes.
Trial report in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02209220 (Impact of Automatic Positive Airway Pressure on Treatment Compliance in Obstructive Sleep Apnea Patients Awaiting Bariatric Surgery), which is not on this map. Cited by 97 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Automatic Positive Airway Pressure on Treatment Compliance in Obstructive Sleep Apnea Patients Awaiting Bariatric Surgery
Who cites it
97 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Guideline for the Management of Obesity in Adult Patients With Obstructive Sleep Apnea.Clinical and experimental otorhinolaryngology · 2026Guideline
- American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022Guideline
- Directed preconception health programs and interventions for improving pregnancy outcomes for women who are overweight or obese.The Cochrane database of systematic reviews · 2015Pooled it
- A weight-loss Mediterranean diet/lifestyle intervention ameliorates inflammation and oxidative stress in patients with obstructive sleep apnea: results of the "MIMOSA" randomized clinical trial.European journal of nutrition · 2021Trial
- Effects of Weight Loss on Obstructive Sleep Apnea Severity. Ten-Year Results of the Sleep AHEAD Study.American journal of respiratory and critical care medicine · 2021Trial
- Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study.Obesity (Silver Spring, Md.) · 2020Trial
- Effectiveness of an intensive weight-loss program for severe OSA in patients undergoing CPAP treatment: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- Heterogeneity of Treatment Effects From an Intensive Lifestyle Weight Loss Intervention on Cardiovascular Events in Patients With Type 2 Diabetes: Data From the Look AHEAD Trial.Diabetes care · 2019Trial
- End-of-Trial Health Outcomes in Look AHEAD Participants who Elected to have Bariatric Surgery.Obesity (Silver Spring, Md.) · 2019Trial
- Gastric Banding Surgery versus Continuous Positive Airway Pressure for Obstructive Sleep Apnea: A Randomized Controlled Trial.American journal of respiratory and critical care medicine · 2018Trial
- Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Trial
- Effects of a lifestyle intervention on REM sleep-related OSA severity in obese individuals with type 2 diabetes.Journal of sleep research · 2017Trial
- Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment.Neurology · 2017Trial
- Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial.International journal of obesity (2005) · 2016 · on this mapTrial
- Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention.Diabetes care · 2016Trial
- Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial.Obesity (Silver Spring, Md.) · 2016Trial
- Trial
- Implications of Look AHEAD for clinical trials and clinical practice.Diabetes, obesity & metabolism · 2014Trial
- Sleep architecture following a weight loss intervention in overweight and obese patients with obstructive sleep apnea and type 2 diabetes: relationship to apnea-hypopnea index.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Trial
- Eight-year weight losses with an intensive lifestyle intervention: the look AHEAD study.Obesity (Silver Spring, Md.) · 2014Trial
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
STUDY
objectivesTo examine whether the initial benefit of weight loss on obstructive sleep apnea (OSA) severity at 1 year is maintained at 4 years.
designRandomized controlled trial with follow-up at 1, 2, and 4 years.
setting4 Look AHEAD clinical centers.
participantsTwo hundred sixty-four obese adults with type 2 diabetes and OSA.
interventionsIntensive lifestyle intervention with a behavioral weight loss program or diabetes support and education. MEASUREMENTS: Change in apnea-hypopnea index on polysomnogram.
resultsThe intensive lifestyle intervention group's mean weight loss was 10.7 ± 0.7 (standard error), 7.4 ± 0.7, and 5.2 ± 0.7 kg at 1, 2, and 4 years respectively, compared to a less than 1-kg weight loss for the control group at each time (P < 0.001). Apnea-hypopnea index difference between groups was 9.7 ± 2.0, 8.0 ± 2.0, and 7.7 ± 2.3 events/h at 1, 2 and 4 years respectively (P < 0.001). Change in apnea-hypopnea index over time was related to the amount of weight loss (P < 0.0001) and intervention, independent of weight loss (P = 0.001). Remission of OSA at 4 years was 5 times more common with intensive lifestyle intervention (20.7%) than diabetes support and education (3.6%).
conclusionsAmong obese adults with type 2 diabetes and OSA, intensive lifestyle intervention produced greater reductions in weight and apnea-hypopnea index over a 4 year period than did diabetes support and education. Beneficial effects of intensive lifestyle intervention on apneahypopnea index at 1 year persisted at 4 years, despite an almost 50% weight regain. Effect of intensive lifestyle intervention on apnea-hypopnea index was largely, but not entirely, due to weight loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.