ArticleJournal of the American Dental Association (1939)2013
Salivary characteristics and dental caries: evidence from general dental practices.
Article in Journal of the American Dental Association (1939), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- A systematic review of salivary gland hypofunction and/or xerostomia induced by non-surgical cancer therapies: prevention strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Autistic individuals have worse oral status than neurotypical controls: a systematic review and meta-analysis of observational studies.Clinical oral investigations · 2024Pooled it
- Influence of sport mouth-formed type mouthguards on saliva secretion and composition during jaw activity: a pilot study.BMC oral health · 2026Trial
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Streptococcus dentisani and Streptococcus mutans in dental biofilm of preschoolers with and without early childhood caries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Hyposalivation Treatment with Non-Crosslinked Hyaluronic Acid and Amino Acids Solution-A Clinical Pilot Study.Life (Basel, Switzerland) · 2026Article
- Does stunting modify the impact of salivary factors and early childhood caries on oral health-related quality of life?BMC public health · 2026Article
- Salivary immune alteration persists after caries treatment.Scientific reports · 2026Article
- Recent Insights on Dental Caries Microbiota in Pediatric Patients with Inborn Errors of Immunity.Advances in experimental medicine and biology · 2026Review
- Association of unstimulated salivary parameters with dental caries in socioeconomically diverse Pakistani school children: a cross-sectional study.BMC oral health · 2025Article
- Environmental Determinants of Early Childhood Caries: A Narrative Synthesis of Observational Evidence and Implications for Global Policy.Dentistry journal · 2025Article
- Dental Caries Status and Salivary Properties of Children with/without Molar Incisor Hypomineralization of 8-16 Years Age in Lucknow: A Comparative Evaluation.International journal of clinical pediatric dentistry · 2025Article
- Oral hygiene status, oral health-related behaviors, sleep, body mass index and dental caries prevalence of a sample aged five from Southwest China: a cross-sectional survey.BMC public health · 2025Article
- The influence of diet, saliva, and dental history on the oral microbiome in healthy, caries-free Australian adults.Scientific reports · 2025Article
- The comparative effect of propolis and chlorhexidine mouthwash on oral nitrite-producing bacteria and blood pressure regulation.Journal of oral microbiology · 2025Article
- A questionnaire based study about knowledge and management of dentin hypersensitivity among dentists.Bioinformation · 2025Article
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- Level of support/commitment and behavior during mealtime and dental care negatively impact the dental caries prevalence in autistic individuals: cross-sectional study.Clinical oral investigations · 2024Article
- Updates on Caries Risk Assessment-A Literature Review.Dentistry journal · 2024Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSaliva is one of the intraoral host factors that influence caries development. The authors conducted a study to investigate whether salivary characteristics are associated with recent dental caries experience.
methodsDentist-investigators and dental staff members collected data pertaining to a two-year cumulative incidence of dental caries (previous 24 months) and salivary characteristics during baseline assessment in an ongoing longitudinal study. The systematic random sample consisted of patients (n = 1,763) visiting general dental practices (n = 63) within the Northwest Practice-based REsearch Collaborative in Evidence-based DENTistry (PRECEDENT). The authors estimated adjusted rate ratios (RRs) by using generalized estimating equations log-linear regression to relate salivary characteristics to coronal carious lesions into dentin.
resultsLow resting pH (≤ 6.0) in the overall sample and low stimulated salivary flow rate (≤ 0.6 milliliter/minute) in older adults (≥ 65 years old) were associated with increased dental caries (RR, 1.6; 95 percent confidence interval [CI], 1.1-2.2; RR, 2.4; 95 percent CI, 1.5-3.8, respectively). Low buffering capacity was associated with decreased dental caries in children and adolescents (RR, 0.3; 95 percent CI, 0.1-1.0; RR, 0.2; 95 percent CI, 0.1-0.7, respectively). A thick, sticky or frothy salivary consistency also was associated with decreased dental caries in adults (RR, 0.6; 95 percent CI, 0.4-1.0). Associations between other salivary characteristics and dental caries for the overall sample and within each age group were not statistically significant.
conclusionsSalivary characteristics were associated weakly with previous dental caries experience, but the authors did not find consistent trends among the three age groups. Different salivary characteristics were associated with an increased caries experience in older adults and a lowered caries experience in children and adolescents and adults. Practical Implications. Further investigations are needed in this population setting to understand the study's conflicting results. The study findings cannot support the use of salivary tests to determine caries risk in actual clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.