ArticleInvestigative ophthalmology & visual science2013
Human photoreceptor outer segments shorten during light adaptation.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 66 citations in OpenAlex.
- Subretinal Aspects of the Optoretinographic Response.Investigative ophthalmology & visual science · 2026Article
- Subretinal aspects of the optoretinographic response.bioRxiv : the preprint server for biology · 2025Article
- Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli.Science advances · 2025Article
- Polarization optical coherence tomography optoretinography: verifying light-induced photoreceptor outer segment shrinkage and subretinal space expansion.Neurophotonics · 2025Article
- Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies.Translational vision science & technology · 2024Article
- The Impact of Photopigment Bleaching on the Human Rod Photoreceptor Subretinal Space Measured Via Optical Coherence Tomography.Investigative ophthalmology & visual science · 2024Article
- Peak Cone Density Predicted from Outer Segment Length Measured on Optical Coherence Tomography.Current eye research · 2024Article
- The outdoor environment affects retinal and choroidal thickness.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Optical coherence tomography in healthy human subjects in the setting of prolonged dark adaptation.Scientific reports · 2023Article
- Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations.Investigative ophthalmology & visual science · 2022Article
- Effects of Monocular Light Deprivation on the Diurnal Rhythms in Retinal and Choroidal Thickness.Investigative ophthalmology & visual science · 2022Article
- Clinical and visual electrophysiological characteristics of vitelliform macular dystrophies in the first decade of life.Indian journal of ophthalmology · 2022Article
- Quantification of intrinsic optical signals in the outer human retina using optical coherence tomography.Annals of the New York Academy of Sciences · 2022Article
- Toward a clinical optoretinogram: a review of noninvasive, optical tests of retinal neural function.Annals of translational medicine · 2021Review
- Functional regulation of an outer retina hyporeflective band on optical coherence tomography images.Scientific reports · 2021Article
- High-Speed, Ultrahigh-Resolution Spectral-Domain OCT with Extended Imaging Range Using Reference Arm Length Matching.Translational vision science & technology · 2020Article
- Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron.Developmental biology · 2020Article
- Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis.Scientific reports · 2020Article
- A recommended "minimum data set" framework for SD-OCT retinal image acquisition and analysis from the Atlas of Retinal Imaging in Alzheimer's Study (ARIAS).Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Impact of Bleaching on Photoreceptors in Different Intermediate AMD Phenotypes.Translational vision science & technology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeBest disease is a macular dystrophy caused by mutations in the BEST1 gene. Affected individuals exhibit a reduced electro-oculographic (EOG) response to changes in light exposure and have significantly longer outer segments (OS) than age-matched controls. The purpose of this study was to investigate the anatomical changes in the outer retina during dark and light adaptation in unaffected and Best disease subjects, and to compare these changes to the EOG.
methodsUnaffected (n = 11) and Best disease patients (n = 7) were imaged at approximately 4-minute intervals during an approximately 40-minute dark-light cycle using spectral domain optical coherence tomography (SD-OCT). EOGs of two subjects were obtained under the same conditions. Automated three-dimensional (3-D) segmentation allowed measurement of light-related changes in the distances between five retinal surfaces.
resultsIn normal subjects, there was a significant decrease in outer segment equivalent length (OSEL) of -2.14 μm (95% confidence interval [CI], -1.77 to -2.51 μm) 10 to 20 minutes after the start of light adaptation, while Best disease subjects exhibited a significant increase in OSEL of 2.07 μm (95% CI, 1.79-2.36 μm). The time course of the change in OS length corresponded to that of the EOG waveform.
conclusionsOur results strongly suggest that the light peak phase of the EOG is temporally related to a decreased OSEL in normal subjects, and the lack of a light peak phase in Best disease subjects is associated with an increase in OSEL. One potential role of Bestrophin-1 is to trigger an increase in the standing potential that approximates the OS to the apical surface of the RPE to facilitate phagocytosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.