ArticleHuman brain mapping2014
Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-Invasive Brain Stimulation for Amyotrophic Lateral Sclerosis: Current Evidence and Future Perspectives.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Voxel-mirrored homotopic connectivity in upper motor neuron-dominant amyotrophic lateral sclerosis is associated with different spread directions.Brain imaging and behavior · 2026Article
- Unveiling structural damage of the corpus callosum in amyotrophic lateral sclerosis through diffusion tensor imaging and spread direction perspectives.Annals of medicine · 2025Observational
- Mapping motor and extra-motor gray and white matter changes in ALS: a comprehensive review of MRI insights.Neuroradiology · 2025Review
- Supra- and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study.Journal of neurology · 2024Article
- Language deficits in primary lateral sclerosis: cortical atrophy, white matter degeneration and functional disconnection between cerebral regions.Journal of neurology · 2024Article
- Italian reference values and brain correlates of verbal fluency index -Amyotrophic lateral sclerosis & frontotemporal degeneration · 2023Article
- Predicting sex, age, general cognition and mental health with machine learning on brain structural connectomes.Human brain mapping · 2023Article
- Profiling morphologic MRI features of motor neuron disease caused byFrontiers in neurology · 2022Article
- Combining structural and metabolic markers in a quantitative MRI study of motor neuron diseases.Annals of clinical and translational neurology · 2021Article
- Upper Motor Neuron Disorders: Primary Lateral Sclerosis, Upper Motor Neuron Dominant Amyotrophic Lateral Sclerosis, and Hereditary Spastic Paraplegia.Brain sciences · 2021Review
- Cortical progression patterns in individual ALS patients across multiple timepoints: a mosaic-based approach for clinical use.Journal of neurology · 2021Article
- The ipsilateral silent period: an early diagnostic marker of callosal disconnection in ALS.Therapeutic advances in chronic disease · 2021Article
- Segmental involvement of the corpus callosum inTherapeutic advances in chronic disease · 2021Article
- Structural and functional brain connectome in motor neuron diseases: A multicenter MRI study.Neurology · 2020Article
- Neuroimaging in genetic frontotemporal dementia and amyotrophic lateral sclerosis.Neurobiology of disease · 2020Review
- Measuring disease progression in primary lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2020Article
- The effect of network thresholding and weighting on structural brain networks in the UK Biobank.NeuroImage · 2020Article
- Structural MRI outcomes and predictors of disease progression in amyotrophic lateral sclerosis.NeuroImage. Clinical · 2020Article
- Identification of Amyotrophic Lateral Sclerosis Based on Diffusion Tensor Imaging and Support Vector Machine.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using diffusion tensor (DT) magnetic resonance imaging (MRI), damage to brain intrahemispheric and interhemispheric connections was assessed in 26 sporadic primary lateral sclerosis (PLS) patients compared with 28 sporadic amyotrophic lateral sclerosis (ALS) patients with similar disability and 35 healthy controls. DT MRI diagnostic accuracy in distinguishing the two motor neuron disease (MND) variants was tested. PLS and ALS patients showed a distributed pattern of abnormalities of the motor system, including the corticospinal tracts and corpus callosum (CC). PLS versus ALS patients showed a more severe damage to the motor CC fibers and subcortical white matter (WM) underlying the primary motor cortices. Both patient groups showed an extra-motor damage, which was more severe in PLS. This did not appear to be driven by longer disease duration in PLS. In PLS patients, damage to the CC mid-body correlated with the severity of upper motor neuron clinical burden. CC fractional anisotropy values had the highest accuracy in distinguishing PLS from controls and ALS. PLS and ALS share an overlapped pattern of WM abnormalities. This underscores that PLS, despite its distinct clinical phenotype and long survival, still lies within the wider MND spectrum. Whether CC diffusivity may be a novel marker to increase confidence in an early diagnostic separation of PLS from ALS still needs to be investigated.
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