SynthesisThe Cochrane database of systematic reviews2013
Intra-articular glucocorticoids for acute gout.
Synthesis in The Cochrane database of systematic reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Colchicine for acute gout.The Cochrane database of systematic reviews · 2021Pooled it
- [Full version of the S2e guidelines on gouty arthritis : Evidence-based guidelines of the German Society of Rheumatology (DGRh)].Zeitschrift fur Rheumatologie · 2016Guideline
- Gout.BMJ clinical evidence · 2015Pooled it
- Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative.Annals of the rheumatic diseases · 2014Pooled it
- Lifestyle interventions for acute gout.The Cochrane database of systematic reviews · 2013Pooled it
- Ultrasound-guided intra-articular injection therapy.BJA education · 2025Review
- Complications Of Colchicine Initiation in a Patient with Chronic Kidney Disease.Journal of Brown hospital medicine · 2024Article
- The Utility of Ultrasound in Evaluating Joint Pain in Systemic Lupus Erythematosus: Looking beyond Fibromyalgia.Journal of personalized medicine · 2023Article
- Current state and prospects of gout treatment in Korea.The Korean journal of internal medicine · 2022Review
- Gouty Arthropathy: Review of Clinical Manifestations and Treatment, with Emphasis on Imaging.Journal of clinical medicine · 2021Review
- Gout Flare Burden, Diagnosis, and Management: Navigating Care in Older Patients with Comorbidity.Drugs & aging · 2021Review
- Injection Techniques for Common Chronic Pain Conditions of the Hand: A Comprehensive Review.Pain and therapy · 2020Review
- Managing Gout Flares in the Elderly: Practical Considerations.Drugs & aging · 2017Article
- Treatment Options for Gout.Deutsches Arzteblatt international · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough intra-articular glucocorticoids are a commonly used intervention in the treatment of acute gout, there is little evidence to support their safety and efficacy in this setting.
objectivesTo evaluate the safety and efficacy of intra-articular glucocorticoids in the treatment of acute gout. SEARCH
methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library), Ovid MEDLINE and Ovid EMBASE for studies to 16th October 2012. We also searched the 2010 to 2011 American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) abstracts and performed a handsearch of the reference lists of articles considered for inclusion. SELECTION CRITERIA: Studies were eligible for inclusion if they were randomised controlled trials (RCTs) or controlled clinical trials (CCTs) that used quasi-randomisation methods to allocate participants to treatment and compared intra-articular glucocorticoids to another therapy (active or placebo) in adults with acute gout. Outcomes selected for inclusion were pain, the proportion of participant withdrawals due to adverse events, inflammation, function, patient global assessment of treatment success, quality of life and proportion of particpants with serious adverse events. DATA COLLECTION AND ANALYSIS: Two review authors independently selected the studies for inclusion and planned to extract the data and perform a risk of bias assessment. MAIN
resultsNo trials were identified that evaluated the efficacy and safety of intra-articular glucocorticoids for acute gout. AUTHORS'
conclusionsThere is presently no evidence from randomised trials to support the use of intra-articular glucocorticoid treatment in acute gout. Evidence suggests intra-articular glucocorticoids may be a safe and effective treatment in osteoarthritis and rheumatoid arthritis. These results may be generalisable to people with acute gout, and the treatment may be especially useful in people when non-steroidal anti-inflammatory drugs or colchicine are contraindicated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.