ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2013
Muscle size, strength, and physical performance and their associations with bone structure in the Hertfordshire Cohort Study.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- The mastoid triangle (Ma-Ast-Po) as a sexually dimorphic feature - a systematic review of 1604 human skulls and meta-analysis.Forensic science, medicine, and pathology · 2025Pooled it
- Research hotspots and trends of sarcopenia in orthopaedic surgery: a bibliometric analysis from 2003 to 2023.Frontiers in surgery · 2025Pooled it
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- Additive prognostic value of functional performance to coronary artery anatomy: the ISCHEMIA trial.European heart journal. Cardiovascular Imaging · 2026Trial
- Trial
- Prevalence, risk factors and adverse health outcomes of osteosarcopenia in middle-aged and older adults with type 2 diabetes mellitus-a scoping review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Review
- Greater DJBMR plus · 2026Article
- Association between hip abductor muscle strength and mobility limitation (locally defined as locomotive syndrome) in community-dwelling adults undergoing osteoporosis screening: a cross-sectional study.BMC musculoskeletal disorders · 2026Article
- Mechanisms and precision interventions in sarcopenia and osteoarthritis comorbidity: A narrative review.Journal of orthopaedic translation · 2026Review
- Comparison of Lower Limb Muscle Strength Imbalances and Gait Performance in Postmenopausal Women with Healthy and Low Bone Mineral Density.International journal of women's health · 2026Article
- Associations between muscle mass and strength and bone microarchitecture in Caucasian postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Association of Sarcopenic Obesity and Osteoporosis in Postmenopausal Women: Risk Factors and Protective Effects of Hormonal Therapy and Nutritional Status.Archives of osteoporosis · 2025Article
- Resistance training-induced appendicular lean tissue mass changes are largely unrelated to pre-training bone characteristics in a larger cohort of untrained adults.Frontiers in physiology · 2025Article
- Muscle parameters in fragility fracture risk prediction in older adults: A scoping review.Journal of cachexia, sarcopenia and muscle · 2024Article
- Article
- Bone damage and health-related quality of life in Hodgkin lymphoma survivors: closing the gaps.Frontiers in oncology · 2024Review
- Evaluation of bone density and hand grip strength in the course of drug treatment for osteoporosis : A real-world study.Orthopadie (Heidelberg, Germany) · 2023Article
- Multidisciplinary approach to sarcopenia: a narrative review.Journal of Yeungnam medical science · 2023Article
- Interactions Between HR-pQCT Bone Density and DJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Reversible Effects of Functional Mandibular Lateral Shift on Masticatory Muscles in Growing Rats.Biomedicines · 2023Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Sarcopenia is associated with a greater fracture risk. This relationship was originally thought to be explained by an increased risk of falls in sarcopenic individuals. However, in addition, there is growing evidence of a functional muscle-bone unit in which bone health may be directly influenced by muscle function. Because a definition of sarcopenia encompasses muscle size, strength, and physical performance, we investigated relationships for each of these with bone size, bone density, and bone strength to interrogate these hypotheses further in participants from the Hertfordshire Cohort Study. A total of 313 men and 318 women underwent baseline assessment of health and detailed anthropometric measurements. Muscle strength was measured by grip strength, and physical performance was determined by gait speed. Peripheral quantitative computed tomography (pQCT) examination of the calf and forearm was performed to assess muscle cross-sectional area (mCSA) at the 66% level and bone structure (radius 4% and 66% levels; tibia 4% and 38% levels). Muscle size was positively associated with bone size (distal radius total bone area β = 17.5 mm2 /SD [12.0, 22.9]) and strength (strength strain index (β = 23.3 mm3 /SD [18.2, 28.4]) amongst women (p < 0.001). These associations were also seen in men and were maintained after adjustment for age, height, weight-adjusted-for-height, limb-length-adjusted-for-height, social class, smoking status, alcohol consumption, calcium intake, physical activity, diabetes mellitus, and in women, years since menopause and estrogen replacement therapy. Although grip strength showed similar associations with bone size and strength in both sexes, these were substantially attenuated after similar adjustment. Consistent relationships between gait speed and bone structure were not seen. We conclude that although muscle size and grip strength are associated with bone size and strength, relationships between gait speed and bone structure and strength were not apparent in this cohort, supporting a role for the muscle-bone unit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.