ArticleThe Journal of clinical endocrinology and metabolism2013
Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.Current obesity reports · 2023Pooled it
- A Systematic Review of Genetic Correlates of Weight Loss After Bariatric Surgery.Obesity surgery · 2021Pooled it
- Utilization of a precision medicine genetic and psychosocial approach in outcome assessment of bariatric weight loss surgery: a narrative review.Frontiers in public health · 2025Review
- Interaction Effects ofGenes · 2024Article
- Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake.International journal of obesity (2005) · 2023Article
- Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery.Journal of clinical medicine · 2023Article
- Establishment of a Nomogram Based on Inflammatory Response-Related Methylation Sites in Intraoperative Visceral Adipose Tissue to Predict EWL% at One Year After LSG.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss.Frontiers in nutrition · 2023Article
- Leveraging Genomic Associations in Precision Digital Care for Weight Loss: Cohort Study.Journal of medical Internet research · 2021Article
- Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction.International journal of molecular sciences · 2021Review
- Factors Affecting Metabolic Outcomes Post Bariatric Surgery: Role of Adipose Tissue.Journal of clinical medicine · 2021Review
- Article
- Pre-operative Predictors of Weight Loss and Weight Regain Following Roux-en-Y Gastric Bypass Surgery: a Prospective Human Study.Obesity surgery · 2020Article
- The AutGO Initiative: A Conceptual Framework for Developing Genetics-Outcomes Research Hypotheses.Autism research : official journal of the International Society for Autism Research · 2020Article
- Genetic Determinants of Weight Loss After Bariatric Surgery.Obesity surgery · 2019Article
- The Challenge of Stratifying Obesity: Attempts in the Quebec Family Study.Frontiers in genetics · 2019Article
- Polygenic risk score for predicting weight loss after bariatric surgery.JCI insight · 2018Article
- From genetics and epigenetics to the future of precision treatment for obesity.Gastroenterology report · 2017Review
- Gene-Diet Interaction and Precision Nutrition in Obesity.International journal of molecular sciences · 2017Review
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
contextRoux-en-Y gastric bypass (RYGB) is among the most effective treatments for extreme obesity and obesity-related complications. However, despite its potential efficacy, many patients do not achieve and/or maintain sufficient weight loss.
objectiveOur objective was to identify genetic factors underlying the variability in weight loss outcomes after RYGB surgery.
designWe conducted a genome-wide association study using a 2-stage phenotypic extreme study design.
settingPatients were recruited from a comprehensive weight loss program at an integrated health system. PATIENTS: Eighty-six obese (body mass index >35 kg/m(2)) patients who had the least percent excess body weight loss (%EBWL) and 89 patients who had the most %EBWL at 2 years after surgery were genotyped using Affymetrix version 6.0 single-nucleotide polymorphism (SNP) arrays. A second group from the same cohort consisting of 164 patients in the lower quartile of %EBWL and 169 from the upper quartile were selected for evaluation of candidate regions using custom SNP arrays.
interventionWe performed RYGB surgery.
main outcome measuresWe assessed %EBWL at 2 years after RYGB and SNPs.
resultsWe identified 111 SNPs in the first-stage analysis whose frequencies were significantly different between 2 phenotypic extremes of weight loss (allelic χ(2) test P < .0001). Linear regression of %EBWL at 2 years after surgery revealed 17 SNPs that approach P < .05 in the validation stage and cluster in or near several genes with potential biological relevance including PKHD1, HTR1A, NMBR, and IGF1R.
conclusionsThis is the first genome-wide association study of weight loss response to RYGB. Variation in weight loss outcomes after RYGB may be influenced by several common genetic variants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.