Evidence map›Paper›PMID 23633161›Full record

ArticlePsychiatric services (Washington, D.C.)2013

Generalizability in the family-to-family education program randomized waitlist-control trial.

Sue M Marcus, Deborah Medoff, Li Juan Fang, James Weaver, Naihua Duan, Alicia Lucksted, Lisa B Dixon

Abstract read
In one paragraph

Article in Psychiatric services (Washington, D.C.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Family Recovery.Community mental health journal · 2015
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sue M MarcusDepartments of Psychiatry and Biostatistics, Division of Biostatistics, New York State Psychiatric Institute, Columbia University, New York City 10032, USA.
Deborah Medoff
Li Juan Fang
James Weaver
Naihua Duan
Alicia Lucksted
Lisa B Dixon

Funding

Research Methods CoreP30MH090322 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HOAGWOOD, KIMBERLY E. · 2011 to 2015
$8.1M
Research Methods CoreP20MH085983 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARCUS, SUE M · 2010 to 2014
$4.2M
A Randomized Trial of Family to Family EducationR01MH072667 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI DIXON, LISA B. · 2005 to 2008
$2.2M
NIMH NIH HHS 1R01-MH72667-01A1NIMH NIH HHS P20 MH085983NIMH NIH HHS P30 MH090322NIMH NIH HHS P30 MH090322-01NIMH NIH HHS R01 MH072667
6 · The paper itself

Abstract

objectiveRandomized controlled trials (RCTs) may have limited generalizability for the community when a high proportion of individuals refuse randomization or otherwise do not participate-a not uncommon phenomenon. A randomized waitlist-control trial of the Family-to-Family (FTF) education program, a 12-week course offered by the National Alliance on Mental Illness for family members of adults with mental illness, was previously reported. This study assessed whether the RCT-derived estimates of effectiveness of FTF were generalizable to individuals who participated in FTF but declined participation in the RCT.

methodsPropensity score matching was used to create five quintiles, each containing scores for individuals in FTF or waitlist conditions and for decliners; scores were matched on multiple baseline characteristics (N=442) within each quintile. Effectiveness estimates, with standard errors, were derived for the decliner population on the basis of effectiveness estimates derived from participants in the RCT; estimates were weighted to the baseline distribution of quintiles for the decliners.

resultsFor each outcome, estimates of the effect sizes observed in the RCT were very similar to the effect sizes observed for the decliner population; confidence intervals also had a high degree of overlap.

conclusionsThis study suggests that the benefits of FTF observed in the RCT are generalizable to the group of individuals who declined RCT participation, providing further evidence of FTF's effectiveness. Propensity score matching was a useful statistical tool for addressing selection bias resulting from high rates of nonconsent in randomized waitlist-control trials.

Indexed as

Data Interpretation, StatisticalAdultAgedAged, 80 and overFamilyHumansMental DisordersMiddle AgedPatient Education as TopicPropensity ScoreRandomized Controlled Trials as TopicRefusal to ParticipateTreatment OutcomeWaiting ListsYoung Adult

Identifiers

PMID23633161
PMCPMC5639322

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.