Observational studyPediatric nephrology (Berlin, Germany)2013
Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium.
Observational study in Pediatric nephrology (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of histopathological subtypes associated with steroid-resistant nephrotic syndrome in children: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
- KDOQI US Commentary on the KDIGO 2025 Clinical Practice Guideline for the Management of Nephrotic Syndrome in Children.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2026Review
- When Minimal Becomes Massive: A Case Report of Childhood-Onset Minimal Change Disease Marching to End Stage Renal Disease Despite Modern Immunotherapy.Clinical medicine insights. Case reports · 2026Article
- Rates of idiopathic childhood nephrotic syndrome relapse are lower during the COVID-19 pandemic.Pediatric nephrology (Berlin, Germany) · 2022Article
- Long-Term Outcome of Secondary Steroid-Resistant Nephrotic Syndrome in Chinese Children.Kidney international reports · 2021Article
- Adult survivors of idiopathic childhood onset nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2021Article
- Case Report: Novel Dietary Supplementation Associated With Kidney Recovery and Reduction in Proteinuria in a Dialysis Dependent Patient Secondary to Steroid Resistant Minimal Change Disease.Frontiers in pediatrics · 2021Article
- Podocytopathies.Nature reviews. Disease primers · 2020Review
- CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Observational
- Long-term Outcomes of Childhood Onset Nephrotic Syndrome.Frontiers in pediatrics · 2016Review
- Late steroid resistance in childhood nephrotic syndrome: do we now know more than 40 years ago?Pediatric nephrology (Berlin, Germany) · 2013Article
- Efficacy and Safety of Cyclosporine versus Tacrolimus in Steroid and Cyclophosphamide Resistant Nephrotic Syndrome: A Prospective Study.Indian journal of nephrologyArticle
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Authors and funding
11 authors.
Funding
Abstract
backgroundIdiopathic nephrotic syndrome (NS) in children is classified as steroid sensitive or steroid resistant. Steroid sensitivity typically portends a low risk of permanent renal failure. However, some initially steroid-sensitive patients later develop steroid resistance. These patients with late steroid resistance (LSR) are often treated with immunosuppressant medications, but the effect of these additional drugs on the long-term prognosis of LSR is still unknown.
methodsA retrospective chart review was performed on patients diagnosed with idiopathic NS and subsequent LSR during the 8-year study period from 2002 up to and including 2009, with a minimum of 2 years of follow-up. Primary outcome measures were proteinuria and renal function.
resultsA total of 29 patients were classified as having LSRNS. The majority of patients received treatment with calcineurin inhibitors and/or mycophenolate mofetil. Seven patients received three or more non-steroid immunosuppressant medications. Sustained complete or partial remission was achieved in 69 % of patients. Three developed end-stage renal disease, and all others maintained normal renal function. There were 13 episodes of serious adverse events, none of which were fatal or irreversible.
conclusionMost patients with LSRNS responded to immunosuppressive therapy by reduction or resolution of proteinuria and preservation of renal function. The results suggest that immunosuppressive treatment is a viable option in NS patients who develop LSR.
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