ArticleEuropean journal of nuclear medicine and molecular imaging2013
Improved quantification of small hearts for gated myocardial perfusion imaging.
Article in European journal of nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of adding intravenous nicorandil to standard therapy on cardiac sympathetic nerve activity and myocyte dysfunction in patients with acute decompensated heart failure.European journal of nuclear medicine and molecular imaging · 2015Trial
- Evaluation of Volumetric Reference Ranges for SPECT MPI Parameters and the Predictive Power of Dyssynchrony Parameters: A Cross-Sectional StudyCurrent medical imaging · 2026Article
- The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes.EJNMMI physics · 2024Article
- Comparison of the left ventricular dyssynchrony between stylet-driven and lumen-less lead technique in left bundle branch area pacing using myocardial perfusion scintigraphy.Quantitative imaging in medicine and surgery · 2023Article
- CMR validation of left ventricular volumes and ejection fraction measured by the IQ-SPECT system in patients with small heart size.EJNMMI research · 2023Article
- Left ventricular function and volumes from gated [Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Optimization of Intraventricular Radioactive Concentration forAnnals of nuclear cardiology · 2023Article
- Left ventricular ejection fraction by multigated acquisition scan using planar sodium iodide and cadmium-zinc-telluride cameras: a comparison with two-dimensional echocardiography.Asia Oceania journal of nuclear medicine & biology · 2023Article
- Is SPECT LVEF assessment more accurate than CT at higher heart rates? More evidence for complementary information in multimodality imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Effects of Acquisition Matrix Size on the Accuracy and Repeatability of Parameters of Left Ventricular Function: A Phantom Study for ECG-gated Myocardial SPECT.Annals of nuclear cardiology · 2021Article
- Imaging technology for myocardial perfusion single-photon emission computed tomography 2018 in Japan.Japanese journal of radiology · 2020Article
- Left ventricular ejection fraction determined with the simulation of a very low-dose CZT-SPECT protocol and an additional count-calibration on planar radionuclide angiographic data.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Left Ventricular Diastolic Dysfunction in a Rat Model of Diabetic Cardiomyopathy using ECG-gatedScientific reports · 2018Article
- Left ventricular phase entropy: Novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Artificial neural network retrained to detect myocardial ischemia using a Japanese multicenter database.Annals of nuclear medicine · 2018Article
- Routine evaluation of left ventricular function using CZT-SPECT, with low injected activities and limited recording times.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Diagnostic accuracy of an artificial neural network compared with statistical quantitation of myocardial perfusion images: a Japanese multicenter study.European journal of nuclear medicine and molecular imaging · 2017Article
- Comparison of diagnostic performance of four software packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT.EJNMMI research · 2017Article
- IQ·SPECT technology and its clinical applications using multicenter normal databases.Annals of nuclear medicine · 2017Review
- Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn patients with a small heart, defined as an end-systolic volume (ESV) of ≤20 mL calculated using the Quantitative Gated SPECT (QGS) program, underestimation of ESV and overestimation of ejection fraction (EF) using gated myocardial perfusion imaging are considered errors caused by inappropriate delineation of the left ventricle (LV). The aim of this study was to develop a new method for delineation of the LV and to evaluate it in studies using a digital phantom, normal subjects and patients.
methodsThe active shape-based method for LV delineation, EXINI heart (ExH), was adjusted to more accurately process small hearts. In small hearts, due to the partial volume effect and the short distance to the opposite ventricular wall, the endocardial and the epicardial surfaces are shifted in the epicardial direction depending on the midventricular volume. The adjusted method was evaluated using digital XCAT phantoms with Monte Carlo simulation (8 virtual patients), a Japanese multicentre normal database (69 patients) and consecutive Japanese patients (116 patients). The LV volumes, EF and diastolic parameters derived from ExH and QGS were compared.
resultsThe digital phantom studies showed a mean ESV of 87% ± 9% of the true volume calculated using ExH and 22 % ± 18% calculated using QGS. In the normal database, QGS gave higher EFs in women than in men (71.4 ± 6.0 % vs. 67.2 ± 6.0%, p = 0.0058), but ExH gave comparable EFs (70.7 ± 4.9% and 71.4 ± 5 % in men and women, respectively, p = ns). QGS gave higher EFs in subjects with a small heart than in those with a normal-sized heart (74.5 ± 5.1% vs. 66.1 ± 4.9%), but ExH gave comparable values (70.0 ± 5.9% vs. 71.6 ± 4.2%, respectively, p = ns). In consecutive patients, the average EFs with QGS in patients with ESV >20 mL, 11-20 mL and ≤10 mL were 57.9%, 71.9% and 83.2%, but with ExH the differences among these groups were smaller (65.2%, 67.8% and 71.5%, respectively).
conclusionThe volume-dependent edge correction algorithm was able to effectively reduce the effects on ESV and EF of a small heart. The uniform normal values might be applicable to both men and women and to both small and normal-sized hearts.
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