ArticleThe Journal of allergy and clinical immunology2013
Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Shared DNA methylation signatures in childhood allergy: The MeDALL study.The Journal of allergy and clinical immunology · 2021Pooled it
- Dysregulated tissue immunity in human fatal asthma.Nature communications · 2026Article
- Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation.The Journal of experimental medicine · 2026Article
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- Regulatory T cells enhance Th17 migration in psoriatic arthritis which is reversed by anti-TNF.iScience · 2021Article
- What does elevated TARC/CCL17 expression tell us about eosinophilic disorders?Seminars in immunopathology · 2021Review
- Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease.The Journal of experimental medicine · 2020Article
- Elevated Circulating CD4Lung · 2020Article
- The Role of T Cells and Macrophages in Asthma Pathogenesis: A New Perspective on Mutual Crosstalk.Mediators of inflammation · 2020Article
- Quantitative assessment of airway remodelling and response to allergen in asthma.Respirology (Carlton, Vic.) · 2019Article
- Sialyl Glycan Expression on T Cell Subsets in Asthma: a correlation with disease severity and blood parameters.Scientific reports · 2019Article
- Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Lung-Infiltrating Foxp3Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.Biomedical optics express · 2017Article
- Effect of follicular helper T cells on the pathogenesis of asthma.Experimental and therapeutic medicine · 2017Article
- Regulatory T Cells in Allergy and Asthma.Frontiers in pediatrics · 2017Review
- Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation.Science translational medicine · 2016Article
- T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.The Journal of clinical investigation · 2016Article
- Donor-derived exosomes induce specific regulatory T cells to suppress immune inflammation in the allograft heart.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundInduction of endogenous regulatory T (Treg) cells represents an exciting new potential modality for treating allergic diseases, such as asthma. Treg cells have been implicated in the regulation of asthma, but the anatomic location in which they exert their regulatory function and the mechanisms controlling the migration necessary for their suppressive function in asthma are not known. Understanding these aspects of Treg cell biology will be important for harnessing their power in the clinic.
objectiveWe sought to determine the anatomic location at which Treg cells exert their regulatory function in the sensitization and effector phases of allergic asthma and to determine the chemokine receptors that control the migration of Treg cells to these sites in vivo in both mice and human subjects.
methodsThe clinical efficacy and anatomic location of adoptively transferred chemokine receptor-deficient CD4(+)CD25(+) forkhead box protein 3-positive Treg cells was determined in the sensitization and effector phases of allergic airway inflammation in mice. The chemokine receptor expression profile was determined on Treg cells recruited into the human airway after bronchoscopic segmental allergen challenge of asthmatic patients.
resultsWe show that CCR7, but not CCR4, is required on Treg cells to suppress allergic airway inflammation during the sensitization phase. In contrast, CCR4, but not CCR7, is required on Treg cells to suppress allergic airway inflammation during the effector phase. Consistent with our murine studies, human subjects with allergic asthma had an increase in CCR4-expressing functional Treg cells in the lungs after segmental allergen challenge.
conclusionThe location of Treg cell function differs during allergic sensitization and allergen-induced recall responses in the lung, and this differential localization is critically dependent on differential chemokine function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.