ReviewDevelopmental and comparative immunology2014
Conventional and non-conventional Drosophila Toll signaling.
Review in Developmental and comparative immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
91 citing papers in PubMed, 166 citations in OpenAlex.
- Insect immunity unveiled: exploring the molecular and cellular defenses against microbial threats.Archives of microbiology · 2026Review
- Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections.EMBO reports · 2026Article
- The insect Toll pathway activates antibacterial immunity against the citrus Huanglongbing pathogen.Nature communications · 2026Article
- The Fat Body: Structure and Functions.Advances in experimental medicine and biology · 2026Review
- GαCell communication and signaling : CCS · 2025Article
- Article
- Characterization of transcriptomics during aging and genes required for lifespan in Drosophila intestine.Scientific reports · 2025Article
- Molecular Assessment of Genes Linked to Honeybee Health Fed with Different Diets in Nuclear Colonies.Insects · 2025Article
- Article
- Innate Immunity Toll-Like Triad TLR6-1-10 and Its Diversity in Distinct Horse Breeds.Veterinary medicine and science · 2025Article
- PxDorsal Regulates the Expression of Antimicrobial Peptides and Affects the Bt Susceptibility ofInsects · 2025Article
- Article
- Paracoccidioides lutzii Infects Galleria mellonella Employing Formamidase as a Virulence Factor.PLoS neglected tropical diseases · 2024Article
- Regulation of ubiquitination and antiviral activity of Cactin by deubiquitinase Usp14 inJournal of virology · 2024Article
- Identification of immunity-related genes distinctly regulated by Manduca sexta Spӓtzle-1/2 and Escherichia coli peptidoglycan.Insect biochemistry and molecular biology · 2024Article
- Dysregulation of innate immune signaling in animal models of spinal muscular atrophy.BMC biology · 2024Article
- Evolution of the Major Components of Innate Immunity in Animals.Journal of molecular evolution · 2024Review
- LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation inZoological research · 2024Article
- Article
- Dysregulation of innate immune signaling in animal models of Spinal Muscular Atrophy.bioRxiv : the preprint server for biology · 2023Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The discovery of Toll in Drosophila and of the remarkable conservation in pathway composition and organization catalyzed a transformation in our understanding of innate immune recognition and response. At the center of that picture is a cascade of interactions in which specific microbial cues activate Toll receptors, which then transmit signals driving transcription factor nuclear localization and activity. Experiments gave substance to the vision of pattern recognition receptors, linked phenomena in development, gene regulation, and immunity into a coherent whole, and revealed a rich set of variations for identifying non-self and responding effectively. More recently, research in Drosophila has illuminated the positive and negative regulation of Toll activation, the organization of signaling events at and beneath membranes, the sorting of information flow, and the existence of non-conventional signaling via Toll-related receptors. Here, we provide an overview of the Toll pathway of flies and highlight these ongoing realms of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.