ArticleEnvironmental health perspectives2013
Exercise attenuates PCB-induced changes in the mouse gut microbiome.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 3 of them syntheses that pooled it.
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Who cites it
156 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effects of Probiotic Supplementation on Sports Performance and Performance-Related Features in Athletes: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Pooled it
- Influence of Exercise on the Human Gut Microbiota of Healthy Adults: A Systematic Review.Clinical and translational gastroenterology · 2020Pooled it
- The Role of Fermentable Fibre on Endurance Exercise Capacity: A Randomised Crossover Trial of Inulin Supplementation.Nutrition bulletin · 2025Trial
- Trial
- Gut-Joint Axis: The Role of Exercise on Gut Microbiota and Acetic Acid Modulation in Obesity-Associated Osteoarthritis Rats.Metabolites · 2026Article
- The Gut Microbiota: An Essential Component in Understanding Pediatric Obesity: A Narrative Review.Nutrients · 2026Review
- Human Intestinal Microbiota Composition Shapes Model Polyfluoroalkyl Substance Biotransformation.Chembiochem : a European journal of chemical biology · 2026Article
- The influence and mechanism of gut microbiota on spermatogenesis.Cell biology and toxicology · 2026Review
- Therapeutic Effects of Low-Intensity Treadmill Exercise on Motor and Non-Motor Symptoms in a 6-Hydroxydopamine (OHDA) Rat Model of Parkinson's Disease via Gut-Brain Axis Modulation.Molecular neurobiology · 2026Article
- The influence of an environmentally relevant polychlorinated biphenyl mixture on the intestinal microbiota in post-weaning mouse dams.Environmental science and pollution research international · 2026Article
- Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture.Journal of hazardous materials · 2025Article
- Gut microbes-muscle axis in muscle function and meat quality.Science China. Life sciences · 2025Review
- Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system.Journal of hazardous materials · 2025Review
- Effects of perfluorolauric acid exposure on intestinal microbial community and physiological health indicators in mice.Scientific reports · 2025Article
- Mechanisms underlying alterations of the gut microbiota by exercise and their role in shaping ecological resilience.FEMS microbiology reviews · 2025Review
- Deciphering the universal role of gut microbiota in pollutant transformation.The ISME journal · 2025Review
- Increased maternal exercise of moderate intensity improves pregnancy outcomes of gestational diabetes mellitus patients through maintaining the balance of the gut microbiota.Frontiers in microbiology · 2025Article
- Determining the level of knowledge and consumption of probiotics and prebiotics among athletes in Jordan.Journal of nutritional science · 2025Article
- The influence of endocrine disruptors on the gut microbiota.Turkish journal of medical sciences · 2025Review
96 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe gut microbiome, a dynamic bacterial community that interacts with the host, is integral to human health because it regulates energy metabolism and immune functions. The gut microbiome may also play a role in risks from environmental toxicants.
objectivesWe investigated the effects of polychlorinated biphenyls (PCBs) and exercise on the composition and structure of the gut microbiome in mice.
methodsAfter mice exercised voluntarily for 5 weeks, they were treated by oral gavage with a mixture of environmentally relevant PCB congeners (PCB153, PCB138, and PCB180; total PCB dose, 150 µmol/kg) for 2 days. We then assessed the microbiome by determination of 16S rRNA using microarray analysis.
resultsOral exposure to PCBs significantly altered the abundance of the gut microbiome in mice primarily by decreasing the levels of Proteobacteria. The activity level of the mice correlated with a substantial shift in abundance, biodiversity, and composition of the microbiome. Importantly, exercise attenuated PCB-induced changes in the gut microbiome.
conclusionsOur results show that oral exposure to PCBs can induce substantial changes in the gut microbiome, which may then influence their systemic toxicity. These changes can be attenuated by behavioral factors, such as voluntary exercise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.