Evidence map›Paper›PMID 23632205›Full record

ArticleGynecologic oncology2013

Endometrial cancer and a family history of cancer.

Linda S Cook, Harold E Nelson, Christine A Stidley, Yan Dong, Pamela J Round, Ernest K Amankwah, Anthony M Magliocco, Christine M Friedenreich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. The proportion of endometrial cancers associated with Lynch syndrome: a systematic review of the literature and meta-analysis.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Linda S CookEpidemiology and Biostatistics, Department of Internal Medicine, NM Health Sciences Center, University of New Mexico, MSC 10 5550, 1 University of New Mexico, Albuquerque, NM 87131-0001, USA. lcook@salud.unm.edu
Harold E Nelson
Christine A Stidley
Yan Dong
Pamela J Round
Ernest K Amankwah
Anthony M Magliocco
Christine M Friedenreich
University of Calgary · CAUniversity of New Mexico · USAlberta Health Services · CA

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Moffitt Postdoctoral Training Program in Molecular & Genetic EpidemiologyR25CA147832 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI EGAN, KATHLEEN M. · 2010 to 2014
$2.0M
NCI NIH HHS 2P30 CA118100-07NCI NIH HHS P30 CA118100NCI NIH HHS R25 CA147832
6 · The paper itself

Abstract

objectiveLynch Syndrome (LS), an inherited genetic syndrome, predisposes to cancers such as colorectal and endometrial. However, the risk for endometrial cancer (EC) in women not affected by LS, but with a family history of cancer, is currently unknown. We examined the association between a family history of cancer and the risk for EC in non-LS patients.

methodsThis population-based case-control study included 519 EC cases and 1015 age-matched controls and took place in Alberta, Canada between 2002 and 2006. Information about risk factors, including family history of cancer in first and second degree relatives, was ascertained via in-person interviews. Microsatellite instability (MSI) status of tumor tissue was assessed to determine involvement of DNA mismatch repair (MMR) genes.

resultsA first or second degree family history of uterine cancer was modestly associated with the risk for overall EC [odds ratio (OR), 1.3; 95% confidence interval (CI), 0.9, 1.9], and the risks were similar for MSI+cancer (OR=1.5, 95%CI=0.7, 3.3) and MSI- cancer (OR=1.3, 95%CI=0.8, 2.4). Although consistent, these associations were modest and not significant. In contrast, the risk for MSI+cancer was elevated with a reported family history of colorectal cancer (OR=1.4, 95%CI=1.0, 2.2), but not for MSI- cancer.

conclusionsA family history of uterine cancer may be modestly associated with EC risk in non-LS patients regardless of MSI status, suggesting that risk was not related to inherited defects in the MMR gene pathway. These results provide preliminary support for an EC-specific genetic syndrome.

Indexed as

AdultAgedCase-Control StudiesEndometrial NeoplasmsFamilyFemaleHumansLogistic ModelsMicrosatellite InstabilityMiddle AgedNeoplasmsRiskBMIbody mass indexCase–control studyCCE+PCIconfidence intervalcontinuous-combined estrogen and progesteroneECendometrial cancerEndometrial cancerE-onlyE+Pestrogen-onlyestrogen plus progesteroneFamily historyHereditary Non-Polyposis Colorectal CancerHNPCCintra-uterine deviceIUDlast menstrual periodLMPLSLynch Syndromemicrosatellite instabilityMicrosatellite instabilitymismatch repairMMRMSInanogramngodds ratioORPCRpolymerase chain reactionRisk factorUCcauterine or colorectal cancer or both

Identifiers

PMID23632205
PMCPMC4052607
OpenAlexW2160903241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.