ArticleEnvironmental health perspectives2013
Blood lead levels and serum insulin-like growth factor 1 concentrations in peripubertal boys.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Associations of Urinary Lead, Cadmium, and Arsenic Exposure with Obesity-Related Indicators Among School-Aged Children: A Longitudinal Study.Biological trace element research · 2026Article
- Circulating Exosomal MicroRNA Profiles Associated with Heavy Metal Exposure and Short Stature in Children.International journal of molecular sciences · 2026Article
- 'Ayurveda', hyperemesis and anaemia in pregnancy.Obstetric medicine · 2025Article
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- The Effect of Environmental Disasters on Endocrine Status, Hematology Parameters, Body Composition, and Physical Performance in Young Soccer Players: A Case Study of the Aral Sea Region.Life (Basel, Switzerland) · 2023Article
- BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism.Scientific reports · 2022Article
- Manganese and Lead Exposure and Early Puberty Onset in Children Living near a Ferromanganese Alloy Plant.International journal of environmental research and public health · 2022Article
- Association of peripubertal blood lead levels with reproductive hormones and semen parameters in a longitudinal cohort of Russian men.Human reproduction (Oxford, England) · 2022Article
- Biological monitoring and health assessment of 21 metal(loid)s in children and adolescents in Liuzhou City, Southwest China.Environmental science and pollution research international · 2022Article
- Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.Exposure and health · 2021Article
- Lead exposure and indices of height and weight in Uruguayan urban school children, considering co-exposure to cadmium and arsenic, sex, iron status and dairy intake.Environmental research · 2021Article
- Prenatal and Early Childhood Exposure to Lead and Repeated Measures of Metabolic Syndrome Risk Indicators From Childhood to Preadolescence.Frontiers in pediatrics · 2021Article
- Heavy metal exposure has adverse effects on the growth and development of preschool children.Environmental geochemistry and health · 2019Article
- Pesticide Exposure and Stunting among Children in Agricultural Areas.The international journal of occupational and environmental medicine · 2019Article
- Lead exposure during childhood and subsequent anthropometry through adolescence in girls.Environment international · 2019Article
- Peripubertal blood lead levels and growth among Russian boys.Environment international · 2017Article
- The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children's Study.Reviews on environmental health · 2017Review
- The association of lead exposure during pregnancy and childhood anthropometry in the Mexican PROGRESS cohort.Environmental research · 2017Article
- Stunting is associated with blood lead concentration among Bangladeshi children aged 2-3 years.Environmental health : a global access science source · 2016Article
- Association of serum lead and mercury level with cardiometabolic risk factors and liver enzymes in a nationally representative sample of adolescents: the CASPIAN-III study.Environmental science and pollution research international · 2014Article
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundChildhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort with low-level lead exposure.
methodsWe recruited 394 boys 8-9 years of age from an industrial Russian town in 2003-2005 and followed them annually thereafter. We used linear regression models to estimate the association of baseline BLLs with serum IGF-1 concentration at two follow-up visits (ages 10-11 and 12-13 years), adjusting for demographic and socioeconomic covariates.
resultsAt study entry, median BLL was 3 μg/dL (range, < 0.5-31 μg/dL), most boys (86%) were prepubertal, and mean ± SD height and BMI z-scores were 0.14 ± 1.0 and -0.2 ± 1.3, respectively. After adjustment for covariates, the mean follow-up IGF-1 concentration was 29.2 ng/mL lower (95% CI: -43.8, -14.5) for boys with high versus low BLL (≥ 5 μg/dL or < 5 μg/dL); this difference persisted after further adjustment for pubertal status. The association of BLL with IGF-1 was stronger for mid-pubertal than prepubertal boys (p = 0.04). Relative to boys with BLLs < 2 μg/dL, adjusted mean IGF-1 concentrations decreased by 12.8 ng/mL (95% CI: -29.9, 4.4) for boys with BLLs of 3-4 μg/dL; 34.5 ng/mL (95% CI: -53.1, -16.0) for BLLs 5-9 μg/dL; and 60.4 ng/mL (95% CI: -90.9, -29.9) for BLLs ≥ 10 μg/dL.
conclusionsIn peripubertal boys with low-level lead exposure, higher BLLs were associated with lower serum IGF-1. Inhibition of the hypothalamic-pituitary-growth axis may be one possible pathway by which lead exposure leads to growth delay.
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