ReviewThe Journal of biological chemistry2013
Reactive intermediates in cytochrome p450 catalysis.
Review in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed.
- First Biochemical Analysis of the Response of the Scorpion Aegaeobuthus gibbosus (Schenkel, 1947) Upon Exposure to Diflubenzuron.Journal of applied toxicology : JAT · 2026Article
- A Self-Cascade Nanozyme of Metformin-Stabilized Amorphous Iron Oxide With Ultrahigh Fe(II) for Potent Tumor Therapy at Ultralow Dose.Angewandte Chemie (International ed. in English) · 2026Article
- High-Valent Late Transition Metal-Oxo Complexes: Breaking Boundaries at the Oxo Wall and Beyond.Chemical reviews · 2026Review
- Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective.Journal of medicinal chemistry · 2026Review
- Can ferric-oxyl excited states explain elongated iron-oxygen bonds in heme peroxidase catalytic intermediates?Nature communications · 2026Article
- Regulation of ferryl reactivity by the cytochrome P450 decarboxylase OleT.Journal of inorganic biochemistry · 2025Article
- Intramolecular Oxo Atom Migration to theJournal of the American Chemical Society · 2025Article
- Structural insights into S-lignin O-demethylation via a rare class of heme peroxygenase enzymes.Nature communications · 2025Article
- Mechanistic Insights into CYP199A4-Catalyzed α-Hydroxyketone Formation and Hydrogen Bond-Assisted C-C Bond Cleavage Catalyzed by the CYP199A4 F182L Mutant.International journal of molecular sciences · 2025Article
- Exploring the influence of H-bonding and ligand constraints on thiolate ligated non-heme iron mediated dioxygen activation.Chemical science · 2024Article
- Cryoradiolysis of oxygenated cytochrome P450 17A1 with lyase substrates generates expected products.Journal of inorganic biochemistry · 2024Article
- Lifting iron higher and higher.Nature chemistry · 2024Article
- Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α-Demethylation.Angewandte Chemie (International ed. in English) · 2024Article
- Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases.Nature reviews. Chemistry · 2024Review
- Dual factors required for cytochrome-P450-mediated hydrocarbon ring contraction in bacterial gibberellin phytohormone biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Light Alters the NHAngewandte Chemie (International ed. in English) · 2023Article
- Sustainable Wacker-Type Oxidations.Angewandte Chemie (International ed. in English) · 2022Review
- Heme compound II models in chemoselectivity and disproportionation reactions.Chemical science · 2022Article
- Rational Design of P450 aMOx for Improving Anti-Markovnikov Selectivity Based on the "Butterfly" Model.Frontiers in molecular biosciences · 2022Article
- Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future.Advances in pharmacology (San Diego, Calif.) · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Recently, we reported the spectroscopic and kinetic characterizations of cytochrome P450 compound I in CYP119A1, effectively closing the catalytic cycle of cytochrome P450-mediated hydroxylations. In this minireview, we focus on the developments that made this breakthrough possible. We examine the importance of enzyme purification in the quest for reactive intermediates and report the preparation of compound I in a second P450 (P450ST). In an effort to bring clarity to the field, we also examine the validity of controversial reports claiming the production of P450 compound I through the use of peroxynitrite and laser flash photolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.