Evidence map›Paper›PMID 23631946›Full record

ArticleOphthalmology2013

The economic burden of vision loss and eye disorders among the United States population younger than 40 years.

John S Wittenborn, Xinzhi Zhang, Charles W Feagan, Wesley L Crouse, Sundar Shrestha, Alex R Kemper, Thomas J Hoerger, Jinan B Saaddine, Vision Cost-Effectiveness Study Group

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02909985 (Visual Activity Evoked by Infrared in Humans After Dark Adaptation), which is not on this map. Cited by 76 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 2 pooled it
20.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02909985 nacompletednot on this mapstarted 2015, after this paper: background citation

Visual Activity Evoked by Infrared in Humans After Dark Adaptation

TypeinterventionalSponsorUniversity of New MexicoRan2015 to 2016Enrolled21ConditionsAge Related Macular Degeneration, Retinitis Pigmentosa, Congenital Stationary Night Blindness, ColorblindnessArmsTungsten halogen light with narrow bandpass filters
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 187 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. ROQUS: a retinal OCT quality and usability score.Biomedical optics express · 2025
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  12. Stargardt macular dystrophy and therapeutic approaches.The British journal of ophthalmology · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Economic Burden of Vision Loss and Eye Disorders in Iran.Iranian journal of public health · 2023
    Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

John S WittenbornDepartment of Public Health Research, NORC at the University of Chicago, Morrisville, North Carolina 27560, USA. wittenborn-john@norc.org
Xinzhi Zhang
Charles W Feagan
Wesley L Crouse
Sundar Shrestha
Alex R Kemper
Thomas J Hoerger
Jinan B Saaddine
Vision Cost-Effectiveness Study Group
Centers for Disease Control and Prevention · USRTI International · USDuke University · USUniversity of Chicago · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

objectiveTo estimate the economic burden of vision loss and eye disorders in the United States population younger than 40 years in 2012.

designEconometric and statistical analysis of survey, commercial claims, and census data.

participantsThe United States population younger than 40 years in 2012.

methodsWe categorized costs based on consensus guidelines. We estimated medical costs attributable to diagnosed eye-related disorders, undiagnosed vision loss, and medical vision aids using Medical Expenditure Panel Survey and MarketScan data. The prevalence of vision impairment and blindness were estimated using National Health and Nutrition Examination Survey data. We estimated costs from lost productivity using Survey of Income and Program Participation. We estimated costs of informal care, low vision aids, special education, school screening, government spending, and transfer payments based on published estimates and federal budgets. We estimated quality-adjusted life years (QALYs) lost based on published utility values.

main outcome measuresCosts and QALYs lost in 2012.

resultsThe economic burden of vision loss and eye disorders among the United States population younger than 40 years was $27.5 billion in 2012 (95% confidence interval, $21.5-$37.2 billion), including $5.9 billion for children and $21.6 billion for adults 18 to 39 years of age. Direct costs were $14.5 billion, including $7.3 billion in medical costs for diagnosed disorders, $4.9 billion in refraction correction, $0.5 billion in medical costs for undiagnosed vision loss, and $1.8 billion in other direct costs. Indirect costs were $13 billion, primarily because of $12.2 billion in productivity losses. In addition, vision loss cost society 215 000 QALYs.

conclusionsWe found a substantial burden resulting from vision loss and eye disorders in the United States population younger than 40 years, a population excluded from previous studies. Monetizing quality-of-life losses at $50 000 per QALY would add $10.8 billion in additional costs, indicating a total economic burden of $38.2 billion. Relative to previously reported estimates for the population 40 years of age and older, more than one third of the total cost of vision loss and eye disorders may be incurred by persons younger than 40 years. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Indexed as

Cost of IllnessHealth Care CostsAdolescentAdultBlindnessCaregiversChildChild, PreschoolData Interpretation, StatisticalEducation, SpecialEye DiseasesHumansInfantInfant, NewbornModels, EconometricPrevalence

Identifiers

PMID23631946
PMCPMC5304763
OpenAlexW2139162858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.