Evidence map›Paper›PMID 23631575›Full record

SynthesisJournal of periodontology2013

Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta-analysis.

Steven Engebretson, Thomas Kocher

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of periodontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04830969 (Impact of Periodontal Therapy on Patients With Diabetes), which is not on this map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04830969 phase2completednot on this mapstarted 2016, after this paper: background citation

Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study

TypeinterventionalSponsorState University of New York at BuffaloRan2016 to 2021Enrolled116ConditionsDiabetes Mellitus, Type II, PeriodontitisArmsChlorhexidine gluconate oral rinse, Scaling & Root Planing, Soft Picks
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  9. Impact of periodontal disease on outcomes in diabetes.Contemporary clinical trials · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Steven EngebretsonDepartment of Periodontology and Implant Dentistry, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA. spe2002@nyu.edu
Thomas Kocher

Funding

Diabetes and Periodontics Trial - Administrative Center/Study ChairU01DE018902 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI ENGEBRETSON, STEVEN P · 2008 to 2012
$11.1M
NIDCR NIH HHS U01 DE018902
6 · The paper itself

Abstract

contextThe effect of periodontal therapy on diabetes outcomes has not been established.

objectiveThis update examines the effect of periodontal treatment on diabetes outcomes. DATA SOURCES: Literature since October 2009 using MEDLINE. STUDY ELIGIBILITY CRITERIA: Published RCTs including periodontal therapy for diabetic subjects, a metabolic outcome, an untreated control group, and follow-up of 3 months. DATA EXTRACTION: Pre-defined data fields, including study quality indicators were used. DATA SYNTHESIS: A search revealed 56 publications of which 9 met inclusion criteria. Mean change of HbA1c from baseline was compared across treatment groups. Pooled analysis was based on random effects models.

resultsA meta-analysis indicated a mean treatment effect of _0.36% HbA1c (CI _0.54, _0.19) compared to no treatment after periodontal therapy (p < 0.0001). Heterogeneity tests revealed only minimal evidence of publication bias (I2 = 9%). LIMITATIONS: Small sample size and high risk of bias remain problematic for studies of this type. Periodontal therapy varied considerably.

conclusionThe modest reduction in HbA1c observed as a result of periodontal therapy in subjects with type 2 diabetes is consistent with previous systematic reviews. Despite this finding, there is limited confidence in the conclusion due to a lack of multi-centre trials of sufficient sample size are lacking.

Indexed as

Diabetes Mellitus, Type 2Humans

Identifiers

PMID23631575
PMCPMC4100543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.