ArticleAnnals of the New York Academy of Sciences2013
Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies.
Article in Annals of the New York Academy of Sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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42 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.PLoS genetics · 2013Pooled it
- Loss of microbial diversity from human-microbe coevolution: immune, epigenetic, and enteric nervous system mechanisms linking dysbiosis to neuropsychiatric and neurodegenerative diseases.Frontiers in neuroscience · 2026Review
- Block Building Task Identifies Distinct Groups of Left/Right-hand Choice Patterns After Unilateral Peripheral Nerve Injury.Journal of visualized experiments : JoVE · 2025Article
- Perinatal adversities as a common factor underlying the association between atypical laterality and neurodevelopmental disorders: A developmental perspective.Psychophysiology · 2024Review
- Investigating the involvement of the left and right hemisphere in speech production and its correlation with handedness - a repetitive transcranial magnetic stimulation study.Postepy psychiatrii neurologii · 2024Article
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- Exome-wide analysis implicates rare protein-altering variants in human handedness.Nature communications · 2024Article
- Kin selection as a modulator of human handedness: sex-specific, parental and parent-of-origin effects.Evolutionary human sciences · 2024Article
- Does owner handedness influence paw preference in dogs?Animal cognition · 2023Article
- Asymmetric activity of NetrinB controls laterality of the Drosophila brain.Nature communications · 2023Article
- Relations between hemispheric asymmetries of grey matter and auditory processing of spoken syllables in 281 healthy adults.Brain structure & function · 2022Article
- Mapping brain asymmetry in health and disease through the ENIGMA consortium.Human brain mapping · 2022Review
- Environmental and genetic determinants of sensorimotor asymmetries in mother-infant interaction.Frontiers in behavioral neuroscience · 2022Article
- Is Handedness at Five Associated with Prenatal Factors?International journal of environmental research and public health · 2021Article
- Human Lateralization, Maternal Effects and Neurodevelopmental Disorders.Frontiers in behavioral neuroscience · 2021Article
- Non-right-handedness in children born extremely preterm: Relation to early neuroimaging and long-term neurodevelopment.PloS one · 2020Article
- "Brain Connectivity Deviates by Sex and Hemisphere in the First Episode of Schizophrenia"-A Route to the Genetic Basis of Language and Psychosis?Schizophrenia bulletin · 2019Article
- Heritability of language laterality assessed by functional transcranial Doppler ultrasound: a twin study.Wellcome open research · 2019Article
- LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis.Journal of neuroinflammation · 2018Article
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3 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Right- and left-handedness run in families, show greater concordance in monozygotic than dizygotic twins, and are well described by single-locus Mendelian models. Here we summarize a large genome-wide association study (GWAS) that finds no significant associations with handedness and is consistent with a meta-analysis of GWASs. The GWAS had 99% power to detect a single locus using the conventional criterion of P < 5 × 10(-8) for the single locus models of McManus and Annett. The strong conclusion is that handedness is not controlled by a single genetic locus. A consideration of the genetic architecture of height, primary ciliary dyskinesia, and intelligence suggests that handedness inheritance can be explained by a multilocus variant of the McManus DC model, classical effects on family and twins being barely distinguishable from the single locus model. Based on the ENGAGE meta-analysis of GWASs, we estimate at least 40 loci are involved in determining handedness.
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