ArticleBMC gastroenterology2013
Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional study.
Article in BMC gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- European Society for the Study of Coeliac Disease (ESsCD) 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 2: Management, Follow-Up, and Complex Disease Courses.United European gastroenterology journal · 2026Guideline
- Enhancing life with celiac disease: unveiling effective tools for assessing health-related quality of life.Frontiers in immunology · 2024Pooled it
- Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Relevance of HLA-DQB1*02 Allele in the Genetic Predisposition of Children with Celiac Disease: Additional Cues from a Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Symptom Profiles Compatible With Disorders of Gut-Brain Interaction in Individuals With Coeliac Disease on a Long-Term Gluten-Free Diet.United European gastroenterology journal · 2026Article
- Factors associated with adherence to gluten-free diet in patients with concomitant celiac disease and type 1 diabetes.JPGN reports · 2026Article
- Is dieting a double-edged sword? Orthorexia in celiac disease.BMC psychiatry · 2026Article
- Comprehensive cross-cohort analysis reveals global gut microbiome signatures of celiac disease.Communications medicine · 2026Article
- Quality of life in adults with celiac disease in Spain over a decade.Scientific reports · 2026Article
- Socioeconomic, lifestyle and clinical determinants of health-related quality of life in adults with celiac disease: a national cross-sectional study.Frontiers in nutrition · 2026Article
- Celiac disease in children with focus on symptoms and quality of life.Scientific reports · 2025Article
- Management Strategy for Non-Responsive and Refractory Celiac Disease in Adults: A Review Article.Journal of clinical medicine · 2025Review
- Evaluation of Quality of Life in Adult Celiac Patients Living in Lithuania and Their Compliance with a Gluten-Free Diet: A Pilot Study.Medicina (Kaunas, Lithuania) · 2025Article
- Prevalence of oral manifestations in coeliac disease and associated factors.BMC gastroenterology · 2025Article
- Life Challenges and Quality of Life of People Living With Coeliac Disease: Time of Diagnosis Matters.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- Toward Precision Medicine in Celiac Disease: Emerging Roles of Multiomics and Artificial Intelligence.Analytical cellular pathology (Amsterdam) · 2025Review
- Celiac disease screening in children: evaluating the evidence, benefits, and challenges.Frontiers in pediatrics · 2025Review
- Variations in gut microbiota in celiac disease patients: a systematic review.Gastroenterology and hepatology from bed to bench · 2025Review
- Impact of probiotics on gut microbiota composition and clinical symptoms of coeliac disease patients following gluten-free diet.Contemporary clinical trials communications · 2023Article
- Quality of Life Perception among Portuguese Celiac Patients: A Cross-Sectional Study Using the Celiac Disease Questionnaire (CDQ).Nutrients · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence suggests that many coeliac disease patients suffer from persistent clinical symptoms and reduced health-related quality of life despite a strict gluten-free diet. We aimed to find predictors for these continuous health concerns in long-term treated adult coeliac patients.
methodsIn a nationwide study, 596 patients filled validated Gastrointestinal Symptom Rating Scale and Psychological General Well-Being questionnaires and were interviewed regarding demographic data, clinical presentation and treatment of coeliac disease, time and place of diagnosis and presence of coeliac disease-associated or other co-morbidities. Dietary adherence was assessed by a combination of self-reported adherence and serological tests. Odds ratios and 95% confidence intervals were calculated by binary logistic regression.
resultsDiagnosis at working age, long duration and severity of symptoms before diagnosis and presence of thyroidal disease, non-coeliac food intolerance or gastrointestinal co-morbidity increased the risk of persistent symptoms. Patients with extraintestinal presentation at diagnosis had fewer current symptoms than subjects with gastrointestinal manifestations. Impaired quality of life was seen in patients with long duration of symptoms before diagnosis and in those with psychiatric, neurologic or gastrointestinal co-morbidities. Patients with persistent symptoms were more likely to have reduced quality of life.
conclusionsThere were a variety of factors predisposing to increased symptoms and impaired quality of life in coeliac disease. Based on our results, early diagnosis of the condition and consideration of co-morbidities may help in resolving long-lasting health problems in coeliac disease.
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