ArticleNanoscale research letters2013
Cytotoxicity of quantum dots and graphene oxide to erythroid cells and macrophages.
Article in Nanoscale research letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Meta-analysis of cellular toxicity for cadmium-containing quantum dots.Nature nanotechnology · 2016Pooled it
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- Unraveling the potential of graphene quantum dots againstFrontiers in microbiology · 2024Article
- Chitosan-graphene quantum dot based active film as smart wound dressing.Journal of drug delivery science and technology · 2023Article
- Surface charge-dependent mitochondrial response to similar intracellular nanoparticle contents at sublethal dosages.Particle and fibre toxicology · 2021Article
- Cytotoxicity and Bioimaging Study for NHDF and HeLa Cell Lines by Using Graphene Quantum Pins.Nanomaterials (Basel, Switzerland) · 2020Article
- The Low Toxicity of Graphene Quantum Dots is Reflected by Marginal Gene Expression Changes of Primary Human Hematopoietic Stem Cells.Scientific reports · 2019Article
- Expression and significance of quantum dots in RAW 264.7 macrophages.Oncology letters · 2018Article
- Recent progress in nanomaterials for gene delivery applications.Biomaterials science · 2016Review
- Immunotoxicity assessment of CdSe/ZnS quantum dots in macrophages, lymphocytes and BALB/c mice.Journal of nanobiotechnology · 2016Article
- Receptor-targeted, drug-loaded, functionalized graphene oxides for chemotherapy and photothermal therapy.International journal of nanomedicine · 2016Article
- Applications and toxicity of graphene family nanomaterials and their composites.Nanotechnology, science and applications · 2016Review
- Enhanced green fluorescent protein-mediated synthesis of biocompatible graphene.Journal of nanobiotechnology · 2014Article
- Cellular distribution and cytotoxicity of graphene quantum dots with different functional groups.Nanoscale research letters · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Great concerns have been raised about the exposure and possible adverse influence of nanomaterials due to their wide applications in a variety of fields, such as biomedicine and daily lives. The blood circulation system and blood cells form an important barrier against invaders, including nanomaterials. However, studies of the biological effects of nanomaterials on blood cells have been limited and without clear conclusions thus far. In the current study, the biological influence of quantum dots (QDs) with various surface coating on erythroid cells and graphene oxide (GO) on macrophages was closely investigated. We found that QDs posed great damage to macrophages through intracellular accumulation of QDs coupled with reactive oxygen species generation, particularly for QDs coated with PEG-NH2. QD modified with polyethylene glycol-conjugated amine particles exerted robust inhibition on cell proliferation of J744A.1 macrophages, irrespective of apoptosis. Additionally, to the best of our knowledge, our study is the first to have demonstrated that GO could provoke apoptosis of erythroid cells through oxidative stress in E14.5 fetal liver erythroid cells and in vivo administration of GO-diminished erythroid population in spleen, associated with disordered erythropoiesis in mice.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.