ArticleOrganic letters2013
Asymmetric synthesis of anti-β-amino-α-hydroxy esters via dynamic kinetic resolution of β-amino-α-keto esters.
Article in Organic letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Emerging progress in ruthenium-catalyzed transfer and asymmetric transfer hydrogenation.RSC advances · 2026Review
- Catalytic Enantioselective Methods for Synthesis of 1,2-Amino Tertiary Alcohols and Their Analogues.Chemical reviews · 2025Review
- Profiling of Diverse Pyridoxal-5'-Phosphate Dependent Enzymes Reveals Promiscuous Aldolase Activity with (2-Azaaryl)methanamines.Journal of the American Chemical Society · 2025Article
- Enantioselective Transfer Hydrogenation of α-Methoxyimino-β-keto Esters.The Journal of organic chemistry · 2024Article
- Synthesis of α,α-Difluoro-β-amino Ketones fromThe Journal of organic chemistry · 2024Article
- γ-, Diastereo-, and Enantioselective Addition of MEMO-Substituted Allylboron Compounds to Aldimines Catalyzed by Organoboron-Ammonium Complexes.Angewandte Chemie (International ed. in English) · 2018Article
- Synthesis of Complex Glycolates by Enantioconvergent Addition Reactions.Accounts of chemical research · 2017Article
- Palladium-Catalyzed β-Arylation of α-Keto Esters.Organic letters · 2017Article
- Synthesis of Complex Tertiary Glycolates by Enantioconvergent Arylation of Stereochemically Labile α-Keto Esters.Journal of the American Chemical Society · 2017Article
- Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations.Chemical reviews · 2017Article
- Diastereoselective Organocatalytic Addition of α-Angelica Lactone to β-Halo-α-ketoesters.The Journal of organic chemistry · 2017Article
- Preparation of Pd-Loaded Hierarchical FAU Membranes and Testing in Acetophenone Hydrogenation.Molecules (Basel, Switzerland) · 2016Article
- Dynamic kinetic asymmetric cross-benzoin additions of β-stereogenic α-keto esters.Journal of the American Chemical Society · 2014Article
- A new reactivity mode for the diazo group: diastereoselective 1,3-aminoalkylation reaction of β-amino-α-diazoesters to give triazolines.Angewandte Chemie (International ed. in English) · 2014Article
- Dynamic kinetic asymmetric transformations of β-stereogenic α-ketoesters by direct aldolization.Angewandte Chemie (International ed. in English) · 2014Article
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3 authors.
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Abstract
A method for the asymmetric synthesis of enantioenriched anti-α-hydroxy-β-amino acid derivatives by enantioconvergent reduction of the corresponding racemic α-keto esters is presented. The requisite α-keto esters are prepared via Mannich addition of ethyl diazoacetate to imines followed by oxidation of the diazo group with Oxone. Implementation of a recently developed dynamic kinetic resolution of β-substituted-α-keto esters via Ru(II)-catalyzed asymmetric transfer hydrogenation provides the title motif in routinely high diastereo- and enantioselectivity.
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