ArticleBMC genomics2013
Genome-wide transcriptional responses of two metal-tolerant symbiotic Mesorhizobium isolates to zinc and cadmium exposure.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 65 citations in OpenAlex.
- Oxalate-mediated detoxification and bioaccumulation of lead and cadmium inMicrobiology (Reading, England) · 2026Article
- Inoculation with cadmium/lead-tolerant bacteria enhances phytoremediation ofApplied and environmental microbiology · 2026Article
- Distinct and indispensable roles of cell viability and extracellular polymeric substances in Pb mineralization by Sinorhizobium sp. C10.Biodegradation · 2026Article
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- Partners in root nodule symbiosis respond uniquely to heavy metal stresses in a host genotype-dependent manner.Scientific reports · 2025Article
- Horizontal gene transfer of the Mer operon is associated with large effects on the transcriptome and increased tolerance to mercury in nitrogen-fixing bacteria.BMC microbiology · 2024Article
- Iron homeostasis as a cell detoxification mechanism inFrontiers in microbiology · 2024Article
- Isolation of urease-producing bacteria from cocoa farms soils in Santander, Colombia, for cadmium remediation.3 Biotech · 2023Article
- Enhancing remediation potential of heavy metal contaminated soils through synergistic application of microbial inoculants and legumes.Frontiers in microbiology · 2023Article
- Synergistic Interaction between Symbiotic NPlants (Basel, Switzerland) · 2022Article
- Analysis ofMicroorganisms · 2022Article
- Cadmium-tolerant endophytic Pseudomonas rhodesiae strains isolated from Typha latifolia modify the root architecture of Arabidopsis thaliana Col-0 in presence and absence of Cd.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Symbiosis islands of Loteae-nodulatingMicrobial genomics · 2020Article
- Transcriptome Response to Heavy Metals in Sinorhizobium meliloti CCNWSX0020 Reveals New Metal Resistance Determinants That Also Promote Bioremediation by Medicago lupulina in Metal-Contaminated Soil.Applied and environmental microbiology · 2017Article
- Ancient Heavy Metal Contamination in Soils as a Driver of Tolerant Anthyllis vulneraria Rhizobial Communities.Applied and environmental microbiology · 2017Article
- Association mapping reveals novel serpentine adaptation gene clusters in a population of symbiotic Mesorhizobium.The ISME journal · 2017Article
- Design a cadA-targeted DNA probe for screening of potential bacterial cadmium biosorbents.Environmental science and pollution research international · 2016Article
- Survival Strategies of the Plant-Associated Bacterium Enterobacter sp. Strain EG16 under Cadmium Stress.Applied and environmental microbiology · 2016Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMesorhizobium metallidurans STM 2683T and Mesorhizobium sp. strain STM 4661 were isolated from nodules of the metallicolous legume Anthyllis vulneraria from distant mining spoils. They tolerate unusually high Zinc and Cadmium concentrations as compared to other mesorhizobia. This work aims to study the gene expression profiles associated with Zinc or Cadmium exposure and to identify genes involved in metal tolerance in these two metallicolous Mesorhizobium strains of interest for mine phytostabilization purposes.
resultsThe draft genomes of the two Mezorhizobium strains were sequenced and used to map RNAseq data obtained after Zinc or Cadmium stresses. Comparative genomics and transcriptomics allowed the rapid discovery of metal-specific or/and strain-specific genes. Respectively 1.05% (72/6,844) and 0.97% (68/6,994) predicted Coding DNA Sequences (CDS) for STM 2683 and STM 4661 were significantly differentially expressed upon metal exposure. Among these, a significant number of CDS involved in transport (13/72 and 13/68 for STM 2683 and STM 4661, respectively) and sequestration (15/72 and 16/68 for STM 2683 and STM 4661, respectively) were identified. Thirteen CDS presented homologs in both strains and were differentially regulated by Zinc and/or Cadmium. For instance, several PIB-type ATPases and genes likely to participate in metal sequestration were identified. Among the conserved CDS that showed differential regulation in the two isolates, we also found znuABC homologs encoding for a high affinity ABC-type Zinc import system probably involved in Zinc homeostasis. Additionally, global analyses suggested that both metals also repressed significantly the translational machinery.
conclusionsThe comparative RNAseq-based approach revealed a relatively low number of genes significantly regulated in the two Mesorhizobium strains. Very few of them were involved in the non-specific metal response, indicating that the approach was well suited for identifying genes that specifically respond to Zinc and Cadmium. Among significantly up-regulated genes, several encode metal efflux and sequestration systems which can be considered as the most widely represented mechanisms of rhizobial metal tolerance. Downstream functional studies will increase successful phytostabilization strategies by selecting appropriate metallicolous rhizobial partners.
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