ArticleFrontiers in plant science2013
The Arabidopsis NIMIN proteins affect NPR1 differentially.
Article in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
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- First genomic insights into the introgression of almond PPV-Marcus resistance into peach.Frontiers in plant science · 2026Article
- Genome-wide identification and expression analysis ofPlant signaling & behavior · 2025Article
- Transcription factor binding site divergence across maize inbred lines drives transcriptional and phenotypic variation.bioRxiv : the preprint server for biology · 2024Article
- Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses.International journal of molecular sciences · 2024Article
- The Vitis yeshanensis U-box E3 ubiquitin ligase VyPUB21 enhances resistance to powdery mildew by targeting degradation of NIM1-interacting (NIMIN) protein.Plant cell reports · 2024Article
- NPR1, a key immune regulator for plant survival under biotic and abiotic stresses.Molecular cell · 2024Review
- A fungal CFEM-containing effector targets NPR1 regulator NIMIN2 to suppress plant immunity.Plant biotechnology journal · 2024Article
- Enhancement of broad-spectrum disease resistance in wheat through key genes involved in systemic acquired resistance.Frontiers in plant science · 2024Review
- The expression of the NPR1-dependent defense response pathway genes in Persea americana (Mill.) following infection with Phytophthora cinnamomi.BMC plant biology · 2023Article
- Plant Protection against Viruses: An Integrated Review of Plant Immunity Agents.International journal of molecular sciences · 2023Review
- Phosphorylation-mediated inactivation of C3H14 by MPK4 enhances bacterial-triggered immunity in Arabidopsis.Plant physiology · 2022Article
- Need help? Recently identified phosphorylation targets of MAP kinase 4 aid plant immunity.Plant physiology · 2022Article
- A novel strategy for improving watermelon resistance to cucumber green mottle mosaic virus by exogenous boron application.Molecular plant pathology · 2022Article
- Article
- Comparison of the pathway structures influencing the temporal response of salicylate and jasmonate defence hormones inFrontiers in plant science · 2022Review
- Salicylic acid inducible nucleocytoplasmic shuttling of NPR1 fusion proteins in human cells.Biotechnology and bioengineering · 2022Article
- Transcriptome and metabolome analysis of stress tolerance to aluminium in Vitis quinquangularis.Planta · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NON-EXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) is the central regulator of the pathogen defense reaction systemic acquired resistance (SAR). NPR1 acts by sensing the SAR signal molecule salicylic acid (SA) to induce expression of PATHOGENESIS-RELATED (PR) genes. Mechanistically, NPR1 is the core of a transcription complex interacting with TGA transcription factors and NIM1-INTERACTING (NIMIN) proteins. Arabidopsis NIMIN1 has been shown to suppress NPR1 activity in transgenic plants. The Arabidopsis NIMIN family comprises four structurally related, yet distinct members. Here, we show that NIMIN1, NIMIN2, and NIMIN3 are expressed differentially, and that the encoded proteins affect expression of the SAR marker PR-1 differentially. NIMIN3 is expressed constitutively at a low level, but NIMIN2 and NIMIN1 are both responsive to SA. While NIMIN2 is an immediate early SA-induced and NPR1-independent gene, NIMIN1 is activated after NIMIN2, but clearly before PR-1. Notably, NIMIN1, like PR-1, depends on NPR1. In a transient assay system, NIMIN3 suppresses SA-induced PR-1 expression, albeit to a lesser extent than NIMIN1, whereas NIMIN2 does not negatively affect PR-1 gene activation. Furthermore, although binding to the same domain in the C-terminus, NIMIN1 and NIMIN2 interact differentially with NPR1, thus providing a molecular basis for their opposing effects on NPR1. Together, our data suggest that the Arabidopsis NIMIN proteins are regulators of the SAR response. We propose that NIMINs act in a strictly consecutive and SA-regulated manner on the SA sensor protein NPR1, enabling NPR1 to monitor progressing threat by pathogens and to promote appropriate defense gene activation at distinct stages of SAR. In this scenario, the defense gene PR-1 is repressed at the onset of SAR by SA-induced, yet instable NIMIN1.
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