ArticleFrontiers in endocrinology2013
ROS and Sympathetically Mediated Mitochondria Activation in Brown Adipose Tissue Contribute to Methamphetamine-Induced Hyperthermia.
Article in Frontiers in endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Distinct roles of dopamine receptors in HIV latency reversal in a myeloid cell model.Frontiers in immunology · 2026Article
- Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.Cell metabolism · 2022Article
- Methamphetamine signals transcription of IL1β and TNFα in a reactive oxygen species-dependent manner and interacts with HIV-1 Tat to decrease antioxidant defense mechanisms.Frontiers in cellular neuroscience · 2022Article
- Sex differences and Tat expression affect dopaminergic receptor expression and response to antioxidant treatment in methamphetamine-sensitized HIV Tat transgenic mice.Neuropharmacology · 2020Article
- Human Immunodeficiency Virus Type 1 and Methamphetamine-Mediated Mitochondrial Damage and Neuronal Degeneration in Human Neurons.Journal of virology · 2020Article
- Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues.EMBO reports · 2020Article
- Article
- Macrophages and brown adipocytes cross-communicate to modulate a thermogenic program following methamphetamine exposure.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Article
- Thyroid hormone (TAutophagy · 2019Article
- Methamphetamine Augments Concurrent Astrocyte Mitochondrial Stress, Oxidative Burden, and Antioxidant Capacity: Tipping the Balance in HIV-Associated Neurodegeneration.Neurotoxicity research · 2018Article
- Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.The Journal of biological chemistry · 2017Review
- The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation.The Journal of physiology · 2016Article
- Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4.Journal of experimental & clinical cancer research : CR · 2016Article
- Effects of acute and chronic systemic methamphetamine on respiratory, cardiovascular and metabolic function, and cardiorespiratory reflexes.The Journal of physiology · 2016Article
- The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders.Frontiers in microbiology · 2015Review
- Reactive oxygen species scavenger N-acetyl cysteine reduces methamphetamine-induced hyperthermia without affecting motor activity in mice.Temperature (Austin, Tex.)Article
- The heat is on: Molecular mechanisms of drug-induced hyperthermia.Temperature (Austin, Tex.)Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Methamphetamine (Meth) abuse has been shown to induce alterations in mitochondrial function in the brain as well as to induce hyperthermia, which contributes to neurotoxicity and Meth-associated mortality. Brown adipose tissue (BAT), a thermogenic site known to be important in neonates, has recently regained importance since being identified in significant amounts and in correlation with metabolic balance in human adults. Given the high mitochondrial content of BAT and its role in thermogenesis, we aimed to investigate whether BAT plays any role in the development of Meth-induced hyperthermia. By ablating or denervating BAT, we identified a partial contribution of this organ to Meth-induced hyperthermia. BAT ablation decreased temperature by 0.5°C and reduced the length of hyperthermia by 1 h, compared to sham-operated controls. BAT denervation also affected the development of hyperthermia in correlation with decreased the expression of electron transport chain molecules, and increase on PCG1a levels, but without affecting Meth-induced uncoupling protein 1 upregulation. Furthermore, in isolated BAT cells in culture, Meth, but not Norepinephrine, induced H2O2 upregulation. In addition, we found that in vivo Reactive Oxygen Species (ROS) play a role in Meth hyperthermia. Thus, sympathetically mediated mitochondrial activation in the BAT and Meth-induced ROS are key components to the development of hyperthermia in Meth abuse.
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