ArticleFrontiers in physiology2013
Novel insights into obesity and diabetes through genome-scale metabolic modeling.
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Metabolic modelling reveals increased autonomy and antagonism in type 2 diabetic gut microbiota.Molecular systems biology · 2025Article
- Exploring Human Brain Metabolism via Genome-Scale Metabolic Modeling with Highlights on Multiple Sclerosis.ACS chemical neuroscience · 2025Article
- Dissecting metabolic landscape of alveolar macrophage.Scientific reports · 2024Article
- Metabolic Connectome and Its Role in the Prediction, Diagnosis, and Treatment of Complex Diseases.Metabolites · 2024Review
- Article
- Leveraging high-resolution omics data for predicting responses and adverse events to immune checkpoint inhibitors.Computational and structural biotechnology journal · 2023Review
- A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scale.PLoS computational biology · 2022Article
- Disease, Drugs and Dysbiosis: Understanding Microbial Signatures in Metabolic Disease and Medical Interventions.Microorganisms · 2020Review
- Unraveling the molecular heterogeneity in type 2 diabetes: a potential subtype discovery followed by metabolic modeling.BMC medical genomics · 2020Article
- Towards the routine use of in silico screenings for drug discovery using metabolic modelling.Biochemical Society transactions · 2020Review
- An atlas of human metabolism.Science signaling · 2020Article
- Computational Modeling of the Human Microbiome.Microorganisms · 2020Review
- Systems Biology Will Direct Vascular-Targeted Therapy for Obesity.Frontiers in physiology · 2020Article
- Current Status and Future Prospects of Genome-Scale Metabolic Modeling to Optimize the Use of Mesenchymal Stem Cells in Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- The profiles of dysbiotic microbial communities.AIMS microbiology · 2019Review
- Fast automated reconstruction of genome-scale metabolic models for microbial species and communities.Nucleic acids research · 2018Article
- Modelling pyruvate dehydrogenase under hypoxia and its role in cancer metabolism.Royal Society open science · 2017Article
- EGFR Signal-Network Reconstruction Demonstrates Metabolic Crosstalk in EMT.PLoS computational biology · 2016Article
- Understanding the Causes and Implications of Endothelial Metabolic Variation in Cardiovascular Disease through Genome-Scale Metabolic Modeling.Frontiers in cardiovascular medicine · 2016Review
- Networking in metabolism and human disease.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The growing prevalence of metabolic diseases, such as obesity and diabetes, are putting a high strain on global healthcare systems as well as increasing the demand for efficient treatment strategies. More than 360 million people worldwide are suffering from type 2 diabetes (T2D) and, with the current trends, the projection is that 10% of the global adult population will be affected by 2030. In light of the systemic properties of metabolic diseases as well as the interconnected nature of metabolism, it is necessary to begin taking a holistic approach to study these diseases. Human genome-scale metabolic models (GEMs) are topological and mathematical representations of cell metabolism and have proven to be valuable tools in the area of systems biology. Successful applications of GEMs include the process of gaining further biological and mechanistic understanding of diseases, finding potential biomarkers, and identifying new drug targets. This review will focus on the modeling of human metabolism in the field of obesity and diabetes, showing its vast range of applications of clinical importance as well as point out future challenges.
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Registered trials
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