ReviewFrontiers in neural circuits2013
Analyzing the structure and function of neuronal circuits in zebrafish.
Review in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Laboratory-based cellular-level correlative visible-light and X-ray microscopy for 3D evaluation of mouse kidney biopsy.Scientific reports · 2026Article
- Collective intermittent exploration in fish schools is mediated by visual cues.Royal Society open science · 2025Article
- Membrane progesterone receptor γ (paqr5b) is essential for the formation of neurons in the zebrafish olfactory rosette.Scientific reports · 2024Article
- Molecular organization of neuronal cell types and neuromodulatory systems in the zebrafish telencephalon.Current biology : CB · 2024Article
- Novel object recognition in Octopus maya.Animal cognition · 2023Article
- Whole-brain optical access in a small adult vertebrate with two- and three-photon microscopy.iScience · 2022Article
- Characterization of D3 Autoreceptor Function in Whole Zebrafish Brain with Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2022Article
- Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales.The Journal of physiology · 2022Article
- Long lasting anxiety following early life stress is dependent on glucocorticoid signaling in zebrafish.Scientific reports · 2022Article
- Fishing for Contact: Modeling Perivascular Glioma Invasion in the Zebrafish Brain.ACS pharmacology & translational science · 2021Article
- Modeling multi-sensory feedback control of zebrafish in a flow.PLoS computational biology · 2021Article
- Cellular Localization ofBrain sciences · 2020Article
- A virtual reality system to analyze neural activity and behavior in adult zebrafish.Nature methods · 2020Article
- Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration.Communications biology · 2020Article
- Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders.Nature communications · 2019Article
- The Olfactory System of Zebrafish as a Model for the Study of Neurotoxicity and Injury: Implications for Neuroplasticity and Disease.International journal of molecular sciences · 2019Review
- Rapid olfactory discrimination learning in adult zebrafish.Experimental brain research · 2018Article
- Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system.PloS one · 2018Article
- Expansion microscopy of zebrafish for neuroscience and developmental biology studies.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clever choice of animal models has been instrumental for many breakthrough discoveries in life sciences. One of the outstanding challenges in neuroscience is the in-depth analysis of neuronal circuits to understand how interactions between large numbers of neurons give rise to the computational power of the brain. A promising model organism to address this challenge is the zebrafish, not only because it is cheap, transparent and accessible to sophisticated genetic manipulations but also because it offers unique advantages for quantitative analyses of circuit structure and function. One of the most important advantages of zebrafish is its small brain size, both at larval and adult stages. Small brains enable exhaustive measurements of neuronal activity patterns by optical imaging and facilitate large-scale reconstructions of wiring diagrams by electron microscopic approaches. Such information is important, and probably essential, to obtain mechanistic insights into neuronal computations underlying higher brain functions and dysfunctions. This review provides a brief overview over current methods and motivations for dense reconstructions of neuronal activity and connectivity patterns. It then discusses selective advantages of zebrafish and provides examples how these advantages are exploited to study neuronal computations in the olfactory bulb.
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