ArticlePLoS medicine2013
Risk of a second primary cancer after non-melanoma skin cancer in white men and women: a prospective cohort study.
Article in PLoS medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- All-cause mortality in patients with basal and squamous cell carcinoma: A systematic review and meta-analysis.Journal of the American Academy of Dermatology · 2018Pooled it
- Guidelines of care for the management of cutaneous squamous cell carcinoma.Journal of the American Academy of Dermatology · 2018Guideline
- New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway.BMC cancer · 2014Trial
- Risk factors for the development of acral melanoma: A multi-institutional, retrospective cohort study.JAAD international · 2026Article
- Basal Cell Carcinoma Research Landscape Overview via Latent Dirichlet Allocation and HJ-Biplot Analysis.Cancers · 2026Review
- Solar ultraviolet radiation exposure, and incidence of childhood (0-19 years) malignant and non-malignant brain tumour in a US population-based dataset, 2000-2021.European journal of epidemiology · 2026Article
- Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study.Acta dermato-venereologica · 2023Article
- Analysis and prediction of second primary malignancy in patients with breast cancer.Molecular and clinical oncology · 2022Article
- Risk of Non-cutaneous Cancers in Individuals with Basal Cell Carcinoma: A Population-based Cohort Study.Acta dermato-venereologica · 2022Article
- Assessing individual patients' knowledge of benign versus malignant skin lesions in the dermatology clinic population.International journal of women's dermatology · 2022Article
- Interest and Utility ofJournal of skin cancer · 2022Article
- Premalignant lesions, basal cell carcinoma and melanoma in patients with cutaneous squamous cell carcinoma.Archives of dermatological research · 2021Article
- Sunscreen application technique amongst patients with a history of skin cancer.Archives of dermatological research · 2020Article
- Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma.The Journal of investigative dermatology · 2019Article
- Compliance with Multiple Health Behaviour Recommendations: A Cross-Sectional Comparison between Female Cancer Survivors and Those with no Cancer History.International journal of environmental research and public health · 2019Article
- Risk of Second Primary Cancer in People with Non-melanoma Skin Cancer: A Nationwide Cohort Study.Cancer research and treatment · 2018Article
- Epidemiology of Keratinocyte Carcinoma.Current dermatology reports · 2017Article
- History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study.Journal of the National Cancer Institute · 2017Article
- Risk of second primary cancer associated with pre-diagnostic smoking, alcohol, and obesity in women with keratinocyte carcinoma.Cancer epidemiology · 2017Article
- Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies suggest a positive association between history of non-melanoma skin cancer (NMSC) and risk of subsequent cancer at other sites. The purpose of this study is to prospectively examine the risk of primary cancer according to personal history of NMSC. METHODS AND
findingsIn two large US cohorts, the Health Professionals Follow-up Study (HPFS) and the Nurses' Health Study (NHS), we prospectively investigated this association in self-identified white men and women. In the HPFS, we followed 46,237 men from June 1986 to June 2008 (833,496 person-years). In the NHS, we followed 107,339 women from June 1984 to June 2008 (2,116,178 person-years). We documented 29,447 incident cancer cases other than NMSC. Cox proportional hazard models were used to calculate relative risks (RRs) and 95% confidence intervals (CIs). A personal history of NMSC was significantly associated with a higher risk of other primary cancers excluding melanoma in men (RR=1.11; 95% CI 1.05-1.18), and in women (RR=1.20; 95% CI 1.15-1.25). Age-standardized absolute risk (AR) was 176 in men and 182 in women per 100,000 person-years. For individual cancer sites, after the Bonferroni correction for multiple comparisons (n=28), in men, a personal history of NMSC was significantly associated with an increased risk of melanoma (RR=1.99, AR=116 per 100,000 person-years). In women, a personal history of NMSC was significantly associated with an increased risk of breast (RR=1.19, AR=87 per 100,000 person-years), lung (RR=1.32, AR=22 per 100,000 person-years), and melanoma (RR=2.58, AR=79 per 100,000 person-years).
conclusionThis prospective study found a modestly increased risk of subsequent malignancies among individuals with a history of NMSC, specifically breast and lung cancer in women and melanoma in both men and women.
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Registered trials
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