ArticleInternational journal of medical sciences2013
Why is saline so acidic (and does it really matter?).
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06632184 (Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy), which is not on this map. Cited by 37 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Comparative Study on the Efficacy of Multimodal Management With Peritoneal Lavage Using Saline Solution Versus Saline Solution With Ondansetron in Laparoscopic Cholecystectomy
Who cites it
37 citing papers in PubMed.
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- Evaluation of the stability of tigecycline in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy.JAC-antimicrobial resistance · 2025Article
- Enhancing Rose Bengal penetration inTherapeutic delivery · 2024Article
- Revisiting the Use of Normal Saline for Peritoneal Washing in Ovarian Cancer.International journal of molecular sciences · 2023Review
- A system for bioelectronic delivery of treatment directed toward wound healing.Scientific reports · 2023Article
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- Effect of Solubilizing Group on the Antibacterial Activity of Heptamethine Cyanine Photosensitizers.Pharmaceutics · 2023Article
- Pulmonary hypertension in a hemodialysis porcine model: possible unforeseen causes.Renal failure · 2022Article
- Pharmaceutical Development and Design of Thermosensitive Liposomes Based on the QbD Approach.Molecules (Basel, Switzerland) · 2022Article
- Ex vivo study: is it possible to overcome the blurriness caused by holmium laser fragmentation of kidney stones?Urolithiasis · 2022Article
- Viability ofVeterinary world · 2022Article
- Evaluation of Early Markers of Ischemia-reperfusion Injury and Preservation Solutions in a Modified Hindlimb Model of Vascularized Composite Allotransplantation.Transplantation direct · 2022Article
- Degradation kinetic study of ZIF-8 microcrystals with and without the presence of lactic acid.RSC advances · 2021Article
- Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19.European journal of clinical pharmacology · 2021Review
- Peroxynitrous Acid Generated In Situ from Acidified HAntibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Commercial 0.9% saline solution for infusion has a pH around 5.5. There are many reasons for this acidity, some of them still obscure. It is also true that infusion of normal saline can lead to metabolic acidaemia, yet the link between the acidity of saline solution and the acidaemia it can engender is not straightforward. This commentary draws together the known and putative sources of acidity in saline solutions: it turns out that the acidity of saline solution is essentially unrelated to the acidaemia complicating saline infusion.
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