Evidence map›Paper›PMID 23630389›Full record

ReviewJournal of leukocyte biology2013

The B cell helper side of neutrophils.

Andrea Cerutti, Irene Puga, Giuliana Magri

Open access · greenAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Role of Neutrophils on the Ocular Surface.International journal of molecular sciences · 2021
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. The roles of neutrophils in cardiovascular diseases.Frontiers in cardiovascular medicine · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Andrea Cerutti1.Av. Dr. Aiguader 88, 08003 Barcelona, Spain. acerutti@imim.es; Twitter: http://www.imim.es/programesrecerca/inflamacio/en_bcellbiology.html or http://www.icrea.cat/Web/ScientificForm.aspx?key=452.
Irene Puga
Giuliana Magri
Hospital del Mar Research Institute · ES

Funding

Regulation of IgA class switching in the intestinal mucosaP01AI061093 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CUNNINGHAM-RUNDLES, CHARLOTTE · 2004 to 2021
$29.8M
Role of Follicular T Helper Cells In Enhancing Humoral Immunity and ProtectionU19AI096187 · NIAID · EMORY UNIVERSITY · PI DERDEYN, CYNTHIA ANN · 2011 to 2015
$26.5M
Regulation of antibody production by innate signalsR01AI057653 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CERUTTI, ANDREA · 2005 to 2016
$4.3M
Regulation and Function of Immunoglobulin D in Mucosal Immune DefenseU01AI095613 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA · 2011 to 2015
$2.1M
NIAID NIH HHS AI057653NIAID NIH HHS AI07437NIAID NIH HHS AI61093NIAID NIH HHS AI95613NIAID NIH HHS AI96187NIAID NIH HHS P01 AI061093NIAID NIH HHS R01 AI057653NIAID NIH HHS U01 AI095613NIAID NIH HHS U19 AI096187
6 · The paper itself

Abstract

Neutrophils use opsonizing antibodies to enhance the clearance of intruding microbes. Recent studies indicate that splenic neutrophils also induce antibody production by providing helper signals to B cells lodged in the MZ of the spleen. Here, we discuss the B cell helper function of neutrophils in the context of growing evidence indicating that neutrophils function as sophisticated regulators of innate and adaptive immune responses.

Indexed as

AnimalsB-LymphocytesHumansImmunologic FactorsModels, ImmunologicalNeutrophilsImmunologic Factorsantibody productiongranulocytesinnate immunity

Identifiers

PMID23630389
PMCPMC3774846
OpenAlexW2155143037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.