ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- IGH Rearrangement Evolution in AdultHemaSphere · 2023Article
- Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4.Frontiers in immunology · 2018Review
- Role of Sex Hormone Levels and Psychological Stress in the Pathogenesis of Autoimmune Diseases.Cureus · 2017Review
- Human antibody production in transgenic animals.Archivum immunologiae et therapiae experimentalis · 2015Review
- Heavy-chain receptor editing unbound.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- VH replacement in primary immunoglobulin repertoire diversification.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Accumulation of VH Replacement Products in IgH Genes Derived from Autoimmune Diseases and Anti-Viral Responses in Human.Frontiers in immunology · 2014Article
- Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.Frontiers in immunology · 2014Review
- Trials and Tribulations with VH Replacement.Frontiers in immunology · 2014Review
- Internalization of B cell receptors in human EU12 μHC⁺ immature B cells specifically alters downstream signaling events.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
VH replacement provides a unique RAG-mediated recombination mechanism to edit nonfunctional IgH genes or IgH genes encoding self-reactive BCRs and contributes to the diversification of Ab repertoire in the mouse and human. Currently, it is not clear how VH replacement is regulated during early B lineage cell development. In this article, we show that cross-linking BCRs induces VH replacement in human EU12 μHC(+) cells and in the newly emigrated immature B cells purified from peripheral blood of healthy donors or tonsillar samples. BCR signaling-induced VH replacement is dependent on the activation of Syk and Src kinases but is inhibited by CD19 costimulation, presumably through activation of the PI3K pathway. These results show that VH replacement is regulated by BCR-mediated signaling in human immature B cells, which can be modulated by physiological and pharmacological treatments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.