ArticleProceedings of the National Academy of Sciences of the United States of America2013
Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 494 papers, 5 of them syntheses that pooled it.
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Who cites it
494 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Unravelling consensus genomic regions conferring stem-related traits in wheat via meta-QTL analysis.BMC plant biology · 2025Pooled it
- Meta-QTLs for multiple disease resistance involving three rusts in common wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Pooled it
- Meta-QTLs, ortho-meta-QTLs and candidate genes for grain yield and associated traits in wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Genome-wide meta-analysis of QTL for morphological related traits of flag leaf in bread wheat.PloS one · 2022Pooled it
- Advances in gene cloning and functional genomics approaches for wheat (Triticum aestivum L.) improvement.The plant genome · 2026Review
- Current status and future perspective of genomics-assisted breeding in wheat (Breeding science · 2026Article
- Integration and imputation of GBS-derived and DArTseq-derived SNP markers in assessing genetic diversity of bread wheat genotypes.BMC genomics · 2026Article
- Genome-wide assessment of genetic diversity and selective signatures in sunflower (Helianthus annuus L.) using a 10 K SNP array.Scientific reports · 2026Article
- Article
- Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials.Nature biotechnology · 2026Article
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- MAGIC populations: a next-generation framework for dissecting complex quantitative traits and accelerating molecular breeding in crops.Frontiers in plant science · 2026Review
- Optimizing genomic selection models for wheat breeding under contrasting water regimes in a mediterranean environment.Plant methods · 2025Article
- Identification of genetic loci and candidate genes underlying sharp eyespot resistance in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Reconciliation of wheat 660K and 90K SNP arrays and their utilization in dough rheological properties of bread wheat.Journal of advanced research · 2025Article
- Impact of Alien Chromosome Introgression fromPlants (Basel, Switzerland) · 2025Article
- Mapping QTLs for adult-plant resistance to yellow rust in a hard winter wheat population Heyne × Lakin.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Breeding Wheat (Plants (Basel, Switzerland) · 2025Review
- The selection and application of tiller number QTLs in modern wheat breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
434 more citing papers are in PubMed but not listed here.
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Authors and funding
31 authors.
Funding
Abstract
Domesticated crops experience strong human-mediated selection aimed at developing high-yielding varieties adapted to local conditions. To detect regions of the wheat genome subject to selection during improvement, we developed a high-throughput array to interrogate 9,000 gene-associated single-nucleotide polymorphisms (SNP) in a worldwide sample of 2,994 accessions of hexaploid wheat including landraces and modern cultivars. Using a SNP-based diversity map we characterized the impact of crop improvement on genomic and geographic patterns of genetic diversity. We found evidence of a small population bottleneck and extensive use of ancestral variation often traceable to founders of cultivars from diverse geographic regions. Analyzing genetic differentiation among populations and the extent of haplotype sharing, we identified allelic variants subjected to selection during improvement. Selective sweeps were found around genes involved in the regulation of flowering time and phenology. An introgression of a wild relative-derived gene conferring resistance to a fungal pathogen was detected by haplotype-based analysis. Comparing selective sweeps identified in different populations, we show that selection likely acts on distinct targets or multiple functionally equivalent alleles in different portions of the geographic range of wheat. The majority of the selected alleles were present at low frequency in local populations, suggesting either weak selection pressure or temporal variation in the targets of directional selection during breeding probably associated with changing agricultural practices or environmental conditions. The developed SNP chip and map of genetic variation provide a resource for advancing wheat breeding and supporting future population genomic and genome-wide association studies in wheat.
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