ArticleProceedings of the National Academy of Sciences of the United States of America2013
Differential hERG ion channel activity of ultrasmall gold nanoparticles.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Medical importance and pharmacokinetics of gold nanoparticles in the human body.Molecular cancer · 2025Review
- Molecular Docking Approach for Biological Interaction of Green Synthesized Nanoparticles.Molecules (Basel, Switzerland) · 2024Review
- Gold Nanoparticles (AuNPs)-Toxicity, Safety and Green Synthesis: A Critical Review.International journal of molecular sciences · 2024Review
- Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles.Beilstein journal of nanotechnology · 2024Review
- Gold Nanoclusters as Nanoantibiotic Auranofin Analogues.Advanced healthcare materials · 2022Article
- Synthesis and solution isomerization of water-soluble AuNanoscale · 2021Article
- Ventricular voltage-gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation.Clinical and translational medicine · 2021Review
- Toxicity of gold nanoparticles (AuNPs): A review.Biochemistry and biophysics reports · 2021Review
- Anionic nanoparticle-induced perturbation to phospholipid membranes affects ion channel function.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Understanding cellular interactions with nanomaterials: towards a rational design of medical nanodevices.Nanotechnology · 2020Review
- Tuning cell behavior with nanoparticle shape.PloS one · 2020Article
- Interactions of nanomaterials with ion channels and related mechanisms.British journal of pharmacology · 2019Review
- Article
- Size dependent effects of Gold Nanoparticles in ISO-induced Hyperthyroid Rats.Scientific reports · 2018Article
- Conjugating Existing Clinical Drugs With Gold Nanoparticles for Better Treatment of Heart Diseases.Frontiers in physiology · 2018Article
- Identification and Localization of Gold Nanoparticles in Potassium Ion Pores: Implications for Kir Blockade.Cardiology and therapy · 2016Article
- Size-Dependent Toxicity of Gold Nanoparticles on Human Embryonic Stem Cells and Their Neural Derivatives.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Evaluation of potential acute cardiotoxicity of biodegradable nanocapsules in rats by intravenous administration.Toxicology research · 2016Article
- Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry.ACS nano · 2014Article
- Air-blood barrier translocation of tracheally instilled gold nanoparticles inversely depends on particle size.ACS nano · 2014Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the mechanism of toxicity of nanomaterials remains a challenge with respect to both mechanisms involved and product regulation. Here we show toxicity of ultrasmall gold nanoparticles (AuNPs). Depending on the ligand chemistry, 1.4-nm-diameter AuNPs failed electrophysiology-based safety testing using human embryonic kidney cell line 293 cells expressing human ether-á-go-go-Related gene (hERG), a Food and Drug Administration-established drug safety test. In patch-clamp experiments, phosphine-stabilized AuNPs irreversibly blocked hERG channels, whereas thiol-stabilized AuNPs of similar size had no effect in vitro, and neither particle blocked the channel in vivo. We conclude that safety regulations may need to be reevaluated and adapted to reflect the fact that the binding modality of surface functional groups becomes a relevant parameter for the design of nanoscale bioactive compounds.
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Registered trials
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