ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2013
Harnessing technology to improve clinical trials: study of real-time informatics to collect data, toxicities, image response assessments, and patient-reported outcomes in a phase II clinical trial.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Randomized clinical trial protocol: Acceptability and feasibility of combination treatment for cervical precancer among South African women living with HIV (ACT 2).Contemporary clinical trials · 2026Trial
- Phase II Study of a Non-Platinum-Containing Doublet of Paclitaxel and Pemetrexed with Bevacizumab as Initial Therapy for Patients with Advanced Lung Adenocarcinomas.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2016Trial
- Digital symptom monitoring in cancer care: an exploratory evaluation of low uptake and engagement.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- The Current Landscape of Remote Digital Symptom Monitoring for Patients With Lung Cancer: Scoping Review.Journal of medical Internet research · 2026Article
- Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among Women Living with HIV in South Africa: Primary Outcomes from the ACT 2 Randomized Trial.medRxiv : the preprint server for health sciences · 2026Article
- Toward Effective Technology Support in DCTs: Insights from the Trials@Home Proof-of-Concept Trial RADIAL.Journal of medical systems · 2026Article
- Adverse Event Reporting in Cancer Clinical Trials: Incorporating Patient-Reported Methods. A Systematic Scoping Review.The patient · 2024Article
- Article
- Optimal assessment of quality of life for patients with prostate cancer.Therapeutic advances in medical oncology · 2022Review
- Oncology patients' experiences in experimental medicine cancer trials: a qualitative study.BMJ open · 2021Article
- Online monitoring of patient self-reported adverse events in early phase clinical trials: Views from patients, clinicians, and trial staff.Clinical trials (London, England) · 2021Article
- Stakeholders' knowledge, attitudes and practices to pharmacovigilance and adverse drug reaction reporting in clinical trials: a mixed methods study.European journal of clinical pharmacology · 2020Article
- Multidisciplinary Software Design for the Routine Monitoring and Assessment of Pain in Palliative Care Services: The Development of PainCheck.JCO clinical cancer informatics · 2019Article
- Usability of an online application for reporting the burden of side effects in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Linguistic Validation of the US National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events in Korean.Journal of global oncology · 2019Article
- Self-evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study.Cancer medicine · 2018Article
- Caring for caregivers and patients: Research and clinical priorities for informal cancer caregiving.Cancer · 2016Review
- Feasibility and clinical impact of sharing patient-reported symptom toxicities and performance status with clinical investigators during a phase 2 cancer treatment trial.Clinical trials (London, England) · 2016Article
- Longitudinal adverse event assessment in oncology clinical trials: the Toxicity over Time (ToxT) analysis of Alliance trials NCCTG N9741 and 979254.The Lancet. Oncology · 2016Article
- Comparison of CT volumetric measurement with RECIST response in patients with lung cancer.European journal of radiology · 2016Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
purposeIn clinical trials, traditional monitoring methods, paper documentation, and outdated collection systems lead to inaccuracies of study information and inefficiencies in the process. Integrated electronic systems offer an opportunity to collect data in real time. PATIENTS AND
methodsWe created a computer software system to collect 13 patient-reported symptomatic adverse events and patient-reported Karnofsky performance status, semi-automated RECIST measurements, and laboratory data, and we made this information available to investigators in real time at the point of care during a phase II lung cancer trial. We assessed data completeness within 48 hours of each visit. Clinician satisfaction was measured.
resultsForty-four patients were enrolled, for 721 total visits. At each visit, patient-reported outcomes (PROs) reflecting toxicity and disease-related symptoms were completed using a dedicated wireless laptop. All PROs were distributed in batch throughout the system within 24 hours of the visit, and abnormal laboratory data were available for review within a median of 6 hours from the time of sample collection. Manual attribution of laboratory toxicities took a median of 1 day from the time they were accessible online. Semi-automated RECIST measurements were available to clinicians online within a median of 2 days from the time of imaging. All clinicians and 88% of data managers felt there was greater accuracy using this system.
conclusionExisting data management systems can be harnessed to enable real-time collection and review of clinical information during trials. This approach facilitates reporting of information closer to the time of events, and improves efficiency, and the ability to make earlier clinical decisions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.