ArticleThe Journal of cell biology2013
Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Unraveling the role ofZoological research · 2026Article
- Genome-wide transcriptome analysis ofFrontiers in cellular and infection microbiology · 2024Article
- Phase Separation as a Driver of Stem Cell Organization and Function during Development.Journal of developmental biology · 2023Review
- Canonical and non-canonical functions of STAT in germline stem cell maintenance.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Transcription Factors Active in the Anterior Blastema ofBiomolecules · 2021Article
- Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression.Biomolecules · 2021Review
- PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation.Cell reports · 2021Article
- Review
- Article
- PI3K Plays an Essential Role in Planarian Regeneration and Tissue Maintenance.Frontiers in cell and developmental biology · 2021Article
- Planarians recruit piRNAs for mRNA turnover in adult stem cells.Genes & development · 2019Article
- Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarianThe Journal of biological chemistry · 2019Article
- Heterochromatin protein 1 (HP1) is intrinsically required for post-transcriptional regulation of Drosophila Germline Stem Cell (GSC) maintenance.Scientific reports · 2019Article
- Neoblast-enriched zinc finger protein FIR1 triggers local proliferation during planarian regeneration.Protein & cell · 2019Article
- Prospectively Isolated TetraspaninCell · 2018Article
- Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarianGenomics data · 2017Article
- Emerging roles of the histone chaperone CAF-1 in cellular plasticity.Current opinion in genetics & development · 2017Review
- Genome-Wide Analysis of Polyadenylation Events in Schmidtea mediterranea.G3 (Bethesda, Md.) · 2016Article
- SmedOB1 is Required for Planarian Homeostasis and Regeneration.Scientific reports · 2016Article
- A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks.Nucleic acids research · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adult stem cells (ASCs) capable of self-renewal and differentiation confer the potential of tissues to regenerate damaged parts. Epigenetic regulation is essential for driving cell fate decisions by rapidly and reversibly modulating gene expression programs. However, it remains unclear how epigenetic factors elicit ASC-driven regeneration. In this paper, we report that an RNA interference screen against 205 chromatin regulators identified 12 proteins essential for ASC function and regeneration in planarians. Surprisingly, the HP1-like protein SMED-HP1-1 (HP1-1) specifically marked self-renewing, pluripotent ASCs, and HP1-1 depletion abrogated self-renewal and promoted differentiation. Upon injury, HP1-1 expression increased and elicited increased ASC expression of Mcm5 through functional association with the FACT (facilitates chromatin transcription) complex, which consequently triggered proliferation of ASCs and initiated blastema formation. Our observations uncover an epigenetic network underlying ASC regulation in planarians and reveal that an HP1 protein is a key chromatin factor controlling stem cell function. These results provide important insights into how epigenetic mechanisms orchestrate stem cell responses during tissue regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.