ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.Journal of periodontal research · 2026Review
- Downregulation of osteoclast differentiation and activation by the soluble epoxide hydrolase inhibition.The Journal of pharmacology and experimental therapeutics · 2026Article
- Omega-3 attenuates the severity of medication-related osteonecrosis of the jaws in rats treated with zoledronate.PloS one · 2025Article
- Is there a role for essential fatty acids in osteoporosis?European journal of clinical nutrition · 2024Review
- Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model.Journal of dental research · 2024Article
- Effects of fish oil supplementation on bone turnover markers in depression: a pilot study.Frontiers in nutrition · 2024Article
- Potential Mechanisms by Which Hydroxyeicosapentaenoic Acids Regulate Glucose Homeostasis in Obesity.Advances in nutrition (Bethesda, Md.) · 2022Review
- Periodontal Stem Cells Synthesize Maresin Conjugate in Tissue Regeneration 3.Journal of dental research · 2022Article
- Resolvin E1's Antimicrobial Potential AgainstFrontiers in oral health · 2022Article
- Resolvin D1 shows osseous-protectionFrontiers in immunology · 2022Article
- Resolvins as a Treatment Modality in Experimental Periodontitis: A Systematic Review of Preclinical Studies.Cureus · 2022Review
- Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis.Scientific reports · 2021Article
- Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease.International journal of molecular sciences · 2021Review
- The pathophysiology of immunoporosis: innovative therapeutic targets.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Review
- Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review.European journal of oral sciences · 2021Review
- Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation.Frontiers in immunology · 2021Article
- Article
- Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice.Cellular and molecular life sciences : CMLS · 2019Article
- OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Interactions between the immune and skeletal systems in inflammatory bone diseases are well appreciated, but the underlying molecular mechanisms that coordinate the resolution phase of inflammation and bone turnover have not been unveiled. Here we investigated the direct actions of the proresolution mediator resolvin E1 (RvE1) on bone-marrow-cell-derived osteoclasts in an in vitro murine model of osteoclast maturation and inflammatory bone resorption. Investigation of the actions of RvE1 treatment on the specific stages of osteoclast maturation revealed that RvE1 targeted late stages of osteoclast maturation to decrease osteoclast formation by 32.8%. Time-lapse vital microscopy and migration assays confirmed that membrane fusion of osteoclast precursors was inhibited. The osteoclast fusion protein DC-STAMP was specifically targeted by RvE1 receptor binding and was down-regulated by 65.4%. RvE1 did not affect the induction of the essential osteoclast transcription factor nuclear factor of activated T cells c1 (NFATc1) or its nuclear translocation; however, NFATc1 binding to the DC-STAMP promoter was significantly inhibited by 60.9% with RvE1 treatment as shown in electrophoresis mobility shift assay. Our findings suggest that proresolution mediators act directly on osteoclasts, in addition to down-regulation of inflammation, providing a novel mechanism for modulating osteoclast signaling in osteolytic inflammatory disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.