ArticleAntimicrobial agents and chemotherapy2013
Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 88 citations in OpenAlex.
- ISMicrobiology and molecular biology reviews : MMBR · 2024Review
- Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era.Nature reviews. Microbiology · 2024Review
- A Critical Review of AMR Risks Arising as a Consequence of Using Biocides and Certain Metals in Food Animal Production.Antibiotics (Basel, Switzerland) · 2023Review
- Pathogenicity and Antibiotic Resistance Diversity inPathogens (Basel, Switzerland) · 2023Article
- Nasal staphylococci community of healthy pigs and pig-farmers in Aragon (Spain). Predominance and within-host resistome diversity in MRSA-CC398 and MSSA-CC9 lineages.One health (Amsterdam, Netherlands) · 2023Article
- Vancomycin Resistance inMicroorganisms · 2022Review
- Deciphering the genetic network and programmed regulation of antimicrobial resistance in bacterial pathogens.Frontiers in cellular and infection microbiology · 2022Review
- A Small Multihost Plasmid CarryingFrontiers in veterinary science · 2022Article
- Antibiotic resistance and host immune system-induced metal bactericidal control are key factors for microbial persistence in the developing human preterm infant gut microbiome.Frontiers in microbiology · 2022Article
- Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.Microbiology spectrum · 2021Article
- Misidentification of meticillin-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- Environmental Surveillance and Characterization of Antibiotic ResistantAntibiotics (Basel, Switzerland) · 2021Article
- The Effects of Natural Products and Environmental Conditions on Antimicrobial Resistance.Molecules (Basel, Switzerland) · 2021Review
- Gain and loss of antibiotic resistant genes in multidrug resistant bacteria: One Health perspective.Journal of microbiology (Seoul, Korea) · 2021Review
- Article
- A copper-dependent compound restores ampicillin sensitivity in multidrug-resistant Staphylococcus aureus.Scientific reports · 2020Article
- An analysis of the ISMicrobial genomics · 2019Article
- Isolation and Molecular Identification of Virulence, Antimicrobial and Heavy Metal Resistance Genes in Livestock-Associated Methicillin-ResistantPathogens (Basel, Switzerland) · 2019Article
- Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism.Metallomics : integrated biometal science · 2019Article
- Selection and dissemination of antimicrobial resistance in Agri-food production.Antimicrobial resistance and infection control · 2019Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study describes three novel erm(T)-carrying multiresistance plasmids that also harbor cadmium and copper resistance determinants. The plasmids, designated pUR1902, pUR2940, and pUR2941, were obtained from porcine and human methicillin-resistant Staphylococcus aureus (MRSA) of the clonal lineage ST398. In addition to the macrolide-lincosamide-streptogramin B (MLSB) resistance gene erm(T), all three plasmids also carry the tetracycline resistance gene tet(L). Furthermore, plasmid pUR2940 harbors the trimethoprim resistance gene dfrK and the MLSB resistance gene erm(C), while plasmids pUR1902 and pUR2941 possess the kanamycin/neomycin resistance gene aadD. Sequence analysis of approximately 18.1 kb of the erm(T)-flanking region from pUR1902, 20.0 kb from pUR2940, and 20.8 kb from pUR2941 revealed the presence of several copies of the recently described insertion sequence ISSau10, which is probably involved in the evolution of the respective plasmids. All plasmids carried a functional cadmium resistance operon with the genes cadD and cadX, in addition to the multicopper oxidase gene mco and the ATPase copper transport gene copA, which are involved in copper resistance. The comparative analysis of S. aureus RN4220 and the three S. aureus RN4220 transformants carrying plasmid pUR1902, pUR2940, or pUR2941 revealed an 8-fold increase in CdSO4 and a 2-fold increase in CuSO4 MICs. The emergence of multidrug resistance plasmids that also carry heavy metal resistance genes is alarming and requires further surveillance. The colocalization of antimicrobial resistance genes and genes that confer resistance to heavy metals may facilitate their persistence, coselection, and dissemination.
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