ArticleThe Journal of biological chemistry2013
Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
- Gene expression supports a single origin of horns and antlers in hoofed mammals.Communications biology · 2024Article
- Loss of Notch signaling in skeletal stem cells enhances bone formation with aging.Bone research · 2023Article
- Influence of Scaffold Microarchitecture on Angiogenesis and Regulation of Cell Differentiation during the Early Phase of Bone Healing: A Transcriptomics and Histological Analysis.International journal of molecular sciences · 2023Article
- Article
- Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork Cells.Frontiers in cell and developmental biology · 2022Article
- MYOC Promotes the Differentiation of C2C12 Cells by Regulation of the TGF-β Signaling Pathways via CAV1.Biology · 2021Article
- MicroRNA-497-5p stimulates osteoblast differentiation through HMGA2-mediated JNK signaling pathway.Journal of orthopaedic surgery and research · 2020Article
- Macrophages Switch to an Osteo-Modulatory Profile Upon RANKL Induction in a Medaka (JBMR plus · 2020Article
- Morin protects glucocorticoid-induced osteoporosis through regulating the mitogen-activated protein kinase signaling pathway.Journal of natural medicines · 2018Article
- Effects of WNT3A and WNT16 on the Osteogenic and Adipogenic Differentiation of Perivascular Stem/Stromal Cells.Tissue engineering. Part A · 2018Article
- Estradiol‑enhanced osteogenesis of rat bone marrow stromal cells is associated with the JNK pathway.Molecular medicine reports · 2017Article
- Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways.Journal of natural medicines · 2016Article
- Extracellular calcium-binding peptide-modified ceramics stimulate regeneration of calvarial bone defects.Tissue engineering and regenerative medicine · 2016Article
- Targeting P38 Pathway Regulates Bony FormationInternational journal of medical sciences · 2016Article
- Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways.Molecular and cellular biochemistry · 2015Article
- Thermally labile components of aqueous humor potently induce osteogenic potential in adipose-derived mesenchymal stem cells.Experimental eye research · 2015Article
- Structural basis for misfolding in myocilin-associated glaucoma.Human molecular genetics · 2015Article
- CaMKII plays a part in the chondrogenesis of bone marrow-derived mesenchymal stem cells.International journal of clinical and experimental pathology · 2015Article
- Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.Experimental neurology · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Myocilin is a secreted glycoprotein that is expressed in ocular and non-ocular tissues. Mutations in the MYOCILIN gene may lead to juvenile- and adult-onset primary open-angle glaucoma. Here we report that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and plays a role in their differentiation into osteoblasts in vitro and in osteogenesis in vivo. Expression of myocilin was detected in MSCs derived from mouse, rat, and human bone marrow, with human MSCs exhibiting the highest level of myocilin expression. Expression of myocilin rose during the course of human MSC differentiation into osteoblasts but not into adipocytes, and treatment with exogenous myocilin further enhanced osteogenesis. MSCs derived from Myoc-null mice had a reduced ability to differentiate into the osteoblastic lineage, which was partially rescued by exogenous extracellular myocilin treatment. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38, Erk1/2, and JNK MAP kinase signaling pathways as well as up-regulated expression of the osteogenic transcription factors Runx2 and Dlx5. Finally, cortical bone thickness and trabecular volume, as well as the expression level of osteopontin, a known factor of bone remodeling and osteoblast differentiation, were reduced dramatically in the femurs of Myoc-null mice compared with wild-type mice. These data suggest that myocilin should be considered as a target for improving the bone regenerative potential of MSCs and may identify a new role for myocilin in bone formation and/or maintenance in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.