ArticleThe Clinical journal of pain2014
Characteristics of sensitization associated with chronic pain conditions.
Article in The Clinical journal of pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
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- Contribution of Amygdala Histone Acetylation in Early Life Stress-Induced Visceral Hypersensitivity and Emotional Comorbidity.Frontiers in neuroscience · 2022Article
- Chronic Pain Diagnosis Using Machine Learning, Questionnaires, and QST: A Sensitivity Experiment.Diagnostics (Basel, Switzerland) · 2020Article
- Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate.Pharmaceutical research · 2020Article
- Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects.Journal of pain research · 2018Article
- Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation.PloS one · 2018Article
- Pressure Pain Threshold and Anxiety in Adolescent Females With and Without Juvenile Fibromyalgia: A Pilot Study.The Clinical journal of pain · 2017Article
- Risk for Irritable Bowel Syndrome in Fibromyalgia Patients: A National Database Study.Medicine · 2017Observational
- Ambroxol for the treatment of fibromyalgia: science or fiction?Journal of pain research · 2017Article
- Increased Risk of Stroke in Patients With Fibromyalgia: A Population-BASED Cohort Study.Medicine · 2016Article
- A afferent fibers are involved in the pathology of central changes in the spinal dorsal horn associated with myofascial trigger spots in rats.Experimental brain research · 2015Article
- Age-related differences in conditioned pain modulation of sensitizing and desensitizing trends during response dependent stimulation.Behavioural brain research · 2015Article
- Article
- Catechol-O-methyltransferase inhibition alters pain and anxiety-related volitional behaviors through activation of β-adrenergic receptors in the rat.Neuroscience · 2015Article
- Risk for irritable bowel syndrome in fibromyalgia patients: a national database study.Medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo describe and understand varieties and characteristics of sensitization contributing to hyperalgesia in participants with chronic pain conditions.
methodsThermal stimulation was delivered to the face, forearm, and calf of pain-free participants and individuals with irritable bowel syndrome, temporomandibular pain disorder (TMD), and fibromyalgia syndrome (FM). Three-second contacts by a preheated thermode occurred at 30-second intervals in ascending and then in descending series (0.7°C steps).
resultsThermal pain ratings during ascending series were greater at each site in individuals diagnosed with chronic pain. Intense pain at the time of testing further enhanced the ratings at all sites, but mild or moderate clinical pain did not have this effect. Thermal pain in all participants was greater during descending series compared with the ascending series of arm and leg stimulation. The hypersensitivity during the descending series was comparable in pain-free, FM and TMD participants but was increased in duration for arm or leg stimulation of FM participants. DISCUSSION: The widespread sensitization for irritable bowel syndrome and TMD participants does not rely on mechanisms of spatial and temporal summation often invoked to explain widespread hyperalgesia associated with chronic pain. Increased sensitivity during descending series of stimulation of an arm or leg but not the face indicates a propensity for sensitization of nociceptive input to the spinal cord. Abnormally prolonged sensitization for FM participants reveals a unique influence of widespread chronic pain referred to deep somatic tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.