ArticleThe Journal of physiology2013
Apelin acts in the subfornical organ to influence neuronal excitability and cardiovascular function.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis.Frontiers in neuroscience · 2026Review
- Proprotein convertase subtilisin/kexin type 9 and apelin in fibromyalgia syndrome.Archives of rheumatology · 2024Article
- Beneficial effects of Apelin-13 on metabolic diseases and exercise.Frontiers in endocrinology · 2023Review
- The association between regional adiposity, cognitive function, and dementia-related brain changes: a systematic review.Frontiers in medicine · 2023Review
- Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats.Neural regeneration research · 2021Article
- A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.Nature communications · 2021Article
- Circumventricular Organ Apelin Receptor Knockdown Decreases Blood Pressure and Sympathetic Drive Responses in the Spontaneously Hypertensive Rat.Frontiers in physiology · 2021Article
- Increased apelin receptor gene expression in the subfornical organ of spontaneously hypertensive rats.PloS one · 2020Article
- The Apelin/APJ System in Psychosis and Neuropathy.Frontiers in pharmacology · 2020Review
- Brain-derived neurotrophic factor acts at neurons of the subfornical organ to influence cardiovascular function.Physiological reports · 2018Article
- Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Apelinergic System Structure and Function.Comprehensive Physiology · 2017Review
- Neural circuits underlying thirst and fluid homeostasis.Nature reviews. Neuroscience · 2017Review
- Vasopressin V1a receptors mediate the hypertensive effects of [PyrThe Journal of physiology · 2017Article
- Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.Trends in pharmacological sciences · 2015Review
- The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2014Review
- Hydrogen sulfide regulates cardiovascular function by influencing the excitability of subfornical organ neurons.PloS one · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Apelin is an adipocyte-derived hormone involved in the regulation of water balance, food intake and the cardiovascular system partially through actions in the CNS. The subfornical organ (SFO) is a circumventricular organ with identified roles in body fluid homeostasis, cardiovascular control and energy balance. The SFO lacks a normal blood-brain barrier, and is thus able to detect circulating signalling molecules such as angiotensin II and leptin. In this study, we investigated actions of apelin-13, the predominant apelin isoform in brain and circulatory system, on the excitability of dissociated SFO neurons using electrophysiological approaches, and determined the cardiovascular consequences of direct administration into the SFO of anaesthetized rats. Whole cell current clamp recording revealed that bath-applied 100 nm apelin-13 directly influences the excitability of the majority of SFO neurons by eliciting either depolarizing (31.8%, mean 7.0 ± 0.8 mV) or hyperpolarizing (28.6%, mean -10.4 ± 1.8 mV) responses. Using voltage-clamp techniques, we also identified modulatory actions of apelin-13 on specific ion channels, demonstrating that apelin-13 activates a non-selective cationic conductance to depolarize SFO neurons while activation of the delayed rectifier potassium conductance underlies hyperpolarizing effects. In anaesthetized rats, microinjection of apelin into SFO decreased both blood pressure (BP) (mean area under the curve -1492.3 ± 357.1 mmHg.s, n = 5) and heart rate (HR) (-32.4 ± 10.39 beats, n = 5). Our data suggest that circulating apelin can directly affect BP and HR as a consequence of the ability of this peptide to modulate the excitability of SFO neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.