Evidence map›Paper›PMID 23628989›Full record

ArticleMolecular psychiatry2014

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.

G Barry, J A Briggs, D P Vanichkina, E M Poth, N J Beveridge, V S Ratnu, S P Nayler, K Nones, J Hu, T W Bredy and 7 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 243 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
243citing papers in PubMed, 3 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

243 citing papers in PubMed, 3 syntheses or guidelines pooled it, 398 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. RNA splicing in health and disease.Molecular biomedicine · 2026
    Review
  5. Review
  6. Article
  7. Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  8. Microfluidic low-input profiling reveals lncRNA roles in disease.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. The Role of Long Non-Coding RNA in Anxiety Disorders: A Literature Review.International journal of molecular sciences · 2025
    Review
  13. Alteration in CaMolecular biology reports · 2025
    Article
  14. Article
  15. Article
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183 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

G BarryInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
J A BriggsAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
D P VanichkinaInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
E M PothDepartment of Neuroscience, Neurology and Ophthalmology, Center for High-Throughput Biology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
N J Beveridge1] Schizophrenia Research Institute, Sydney, NSW, Australia [2] The University of Newcastle, Callaghan, NSW, Australia.
V S RatnuQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
S P NaylerAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
K NonesQueensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.
J HuWilmer Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
T W BredyQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
S NakagawaRNA Biology Laboratory, RIKEN Advanced Research Institute, Wako, Saitama, Japan.
F RigoIsis Pharmaceuticals, Carlsbad, CA, USA.
R J TaftInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
M J Cairns1] Schizophrenia Research Institute, Sydney, NSW, Australia [2] The University of Newcastle, Callaghan, NSW, Australia.
S BlackshawDepartment of Neuroscience, Neurology and Ophthalmology, Center for High-Throughput Biology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
E J WolvetangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia.
J S Mattick1] Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia [2] Garvan Institute of Medical Research, Sydney, NSW, Australia [3] St Vincent's Clinical School and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
University of Queensland · AUJohns Hopkins University · USUniversity of Newcastle Australia · AUGarvan Institute of Medical Research · AUIonis Pharmaceuticals (United States) · USJohns Hopkins Medicine · USRIKEN Advanced Science Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning. Although defective alternative splicing has been linked to SZ, the molecular mechanisms responsible are unknown. Additionally, there is limited understanding of the early transcriptomic responses to neuronal activation. Here, we profile these transcriptomic responses and show that long non-coding RNAs (lncRNAs) are dynamically regulated by neuronal activation, including acute downregulation of the lncRNA Gomafu, previously implicated in brain and retinal development. Moreover, we demonstrate that Gomafu binds directly to the splicing factors QKI and SRSF1 (serine/arginine-rich splicing factor 1) and dysregulation of Gomafu leads to alternative splicing patterns that resemble those observed in SZ for the archetypal SZ-associated genes DISC1 and ERBB4. Finally, we show that Gomafu is downregulated in post-mortem cortical gray matter from the superior temporal gyrus in SZ. These results functionally link activity-regulated lncRNAs and alternative splicing in neuronal function and suggest that their dysregulation may contribute to neurological disorders.

Indexed as

Gene Expression RegulationAlternative SplicingAnimalsCells, CulturedCerebral CortexElectrophoretic Mobility Shift AssayEmbryo, MammalianErbB ReceptorsHumansImmunoprecipitationMiceMice, Inbred C57BLMicroarray AnalysisNerve Tissue ProteinsNeuronsNuclear ProteinsDISC1 protein, humanERBB4 protein, humanErbb4 protein, mouseErbB ReceptorsMiat long non-coding RNANerve Tissue ProteinsNuclear ProteinsOligonucleotides, AntisenseProteomeQKI protein, humanReceptor, ErbB-4RNA-Binding ProteinsRNA, Long NoncodingSerine-Arginine Splicing Factors

Identifiers

PMID23628989
OpenAlexW2074495242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.