Evidence map›Paper›PMID 23628983›Full record

ArticleMolecular psychiatry2014

White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms.

M-L Paillère Martinot, H Lemaitre, E Artiges, R Miranda, R Goodman, J Penttilä, M Struve, T Fadai, V Kappel, L Poustka and 21 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. White Matter Microstructure in Pediatric Bipolar Disorder and Disruptive Mood Dysregulation Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016
    Review
  14. Article
  15. Article
  16. Article
  17. Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample.Journal of child psychology and psychiatry, and allied disciplines · 2014
    Article
  18. Review
  19. FKBP5 genotype and structural integrity of the posterior cingulum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 12 institutions in 5 countries.

M-L Paillère Martinot1] AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [4] Université Paris-Sud 11, Orsay, France.
H Lemaitre1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France.
E Artiges1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France [4] Psychiatry Department 91G16, Orsay Hospital, Orsay, France.
R Miranda1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France.
R GoodmanInstitute of Psychiatry, King's College London, London, UK.
J PenttiläUniversity of Tampere, School of Medicine, Tampere, Finland.
M StruveDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
T FadaiUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
V KappelDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
L PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
P Conrod1] Institute of Psychiatry, King's College London, London, UK [2] Department of Psychiatry, Université de Montréal, CHU Ste Justine Hospital, Montréal, QC, Canada.
T BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
A BarbotNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
G J BarkerInstitute of Psychiatry, King's College London, London, UK.
C BüchelUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
H FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
J GallinatDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
H Garavan1] Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland [2] Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
A HeinzDepartment of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
B IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany.
C LawrenceSchool of Psychology, University of Nottingham, Nottingham, UK.
E Loth1] Institute of Psychiatry, King's College London, London, UK [2] MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.
K MannDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
T Paus1] School of Psychology, University of Nottingham, Nottingham, UK [2] Rotman Research Institute, University of Toronto, Toronto, ON, Canada [3] Montreal Neurological Institute, McGill University, Toronto, QC, Canada.
Z PausovaDepartment of Physiology and Nutritional Sciences, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
M RietschelDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
T W RobbinsBehavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK.
M N Smolka1] Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany [2] Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany.
G Schumann1] Institute of Psychiatry, King's College London, London, UK [2] MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.
J-L Martinot1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France.
IMAGEN consortium
Charité - Universitätsmedizin Berlin · DEHeidelberg University · DECentral Institute of Mental Health · DEEppendorf (Germany) · DEKing's College London · GBCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRPhysikalisch-Technische Bundesanstalt · DESickKids Foundation · CATampere University · FIUniversity Hospital Heidelberg · DEUniversity of Cambridge · GBUniversity of Nottingham · GB

Funding

Medical Research Council G0001354Medical Research Council G0901858Medical Research Council G1000183
6 · The paper itself

Abstract

Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those alterations would be associated with differences in gray-matter (GM) volumes. Forty-two adolescents with three core manic symptoms and no psychiatric diagnosis, and 126 adolescents matched by age and sex, with no psychiatric diagnosis or symptoms, were identified after screening the IMAGEN database of 2223 young adolescents recruited from the general population. After image quality control, voxel-wise statistics were performed on the diffusion parameters using tract-based spatial statistics in 25 SBP adolescents and 77 controls, and on GM and WM images using voxel-based morphometry in 30 SBP adolescents and 106 controls. As compared with healthy controls, adolescents with SBP displayed lower FA values in a number of WM tracts, particularly in the corpus callosum, cingulum, bilateral superior and inferior longitudinal fasciculi, uncinate fasciculi and corticospinal tracts. Radial diffusivity was mainly higher in posterior parts of bilateral superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculi and right cingulum. As compared with controls, SBP adolescents had lower GM volume in the left anterior cingulate region. This is the first study to investigate WM microstructure and GM morphometric variations in adolescents with SBP. The widespread FA alterations in association and projection tracts, associated with GM changes in regions involved in mood disorders, suggest altered structural connectivity in those adolescents.

Indexed as

AdolescentAnisotropyBipolar DisorderBrainChi-Square DistributionDatabases, FactualFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve Fibers, MyelinatedPsychiatric Status Rating ScalesSelf Report

Identifiers

PMID23628983
PMCPMC3965837
OpenAlexW2146726024

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.