ArticleEmerging infectious diseases2013
Detection of spliced mRNA from human bocavirus 1 in clinical samples from children with respiratory tract infections.
Article in Emerging infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- A Diagnostic Approach to Separate Acute Human Bocavirus 1 Respiratory Tract Infection From Long-lasting Virus Shedding.The Journal of infectious diseases · 2025Article
- The Role of Quantitative PCR in Evaluating the Clinical Significance of Human Bocavirus Detection in Children.Viruses · 2024Article
- Development of RPA-Cas12a-fluorescence assay for rapid and reliable detection of human bocavirus 1.Animal models and experimental medicine · 2024Article
- The Burden of Human Bocavirus 1 in Hospitalized Children With Respiratory Tract Infections.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Viral and Atypical Bacterial Detection in Young Nepalese Children Hospitalized with Severe Pneumonia.Microbiology spectrum · 2021Article
- Persistent human bocavirus 1 infection and tonsillar immune responses.Clinical and translational allergy · 2021Article
- Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium.Current protocols in microbiology · 2020Article
- Current and Future Point-of-Care Tests for Emerging and New Respiratory Viruses and Future Perspectives.Frontiers in cellular and infection microbiology · 2020Review
- Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- Acute human bocavirus 1 infection in child with life-threatening bilateral bronchiolitis and right-sided pneumonia: a case report.Journal of medical case reports · 2019Article
- Serologically diagnosed acute human bocavirus 1 infection in childhood community-acquired pneumonia.Pediatric pulmonology · 2018Article
- Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia.The Journal of infectious diseases · 2017Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- Detection and monitoring of human bocavirus 1 infection by a new rapid antigen test.New microbes and new infections · 2016Article
- Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways.PLoS pathogens · 2016Article
- Article
- Human Bocavirus 1 Primary Infection and Shedding in Infants.The Journal of infectious diseases · 2015Article
- B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human bocavirus 1 (HBoV1) is a parvovirus associated with respiratory tract infections (RTIs) in children, but a causal relation has not yet been confirmed. To develop a qualitative reverse transcription PCR to detect spliced mRNA from HBoV1 and to determine whether HBoV1 mRNA correlated better with RTIs than did HBoV1 DNA, we used samples from HBoV1 DNA-positive children, with and without RTIs, to evaluate the test. A real-time reverse transcription PCR, targeting 2 alternatively spliced mRNAs, was developed. HBoV1 mRNA was detected in nasopharyngeal aspirates from 33 (25%) of 133 children with RTIs but in none of 28 controls (p<0.001). The analytical sensitivity and specificity of the test were good. Our data support the hypothesis that HBoV1 may cause RTIs, and we propose that HBoV1 mRNA could be used with benefit, instead of HBoV1 DNA, as a diagnostic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.