Trial reportThe Journal of pediatrics2013
The impact of short stature on health-related quality of life in children with chronic kidney disease.
Trial report in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00327860 (Chronic Kidney Disease in Children Prospective Cohort Study), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease in Children Prospective Cohort Study (CKiD)
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease.Nature reviews. Nephrology · 2019Guideline
- Impact of chronic kidney disease on health-related quality of life in the pediatric population: meta-analysis.Jornal de pediatriaPooled it
- Eicosanoids as Biomarkers of Hyperfiltration-Mediated Injury in CKD.Kidney international reports · 2026Article
- Nutrition delivery in infants with kidney failure on extracorporeal kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Growth Failure Associated With Parathyroid Hormone Levels in Pediatric Dialysis Patients: A Nationwide Cohort Study.Kidney medicine · 2026Article
- Growth and Recombinant Human Growth Hormone Use in Children with Congenital Chronic Kidney Disease: A Multicentric Contemporary Study.Hormone research in paediatrics · 2026Article
- Ultrasound Screening of Temporomandibular Joint Pathology in Children with Chronic Kidney Disease.Dentistry journal · 2025Article
- Nutritional profile and infection-related hospital admissions in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025Article
- Associations between collagen X biomarker and linear growth velocity in a pediatric chronic kidney disease cohort.Pediatric nephrology (Berlin, Germany) · 2023Article
- Longitudinal changes of health-related quality of life in childhood chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses.Health and quality of life outcomes · 2023Article
- Associations of longitudinal height and weight with clinical outcomes in pediatric kidney replacement therapy: results from the ESPN/ERA Registry.Pediatric nephrology (Berlin, Germany) · 2023Article
- Illness-related parental stress and quality of life in children with kidney diseases.Pediatric nephrology (Berlin, Germany) · 2023Article
- Patient- and caregiver-reported factors associated with school absenteeism in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Article
- The Relationship Between Neighborhood Disadvantage and Kidney Disease Progression in the Chronic Kidney Disease in Children (CKiD) Cohort.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Observational
- Impact of Metabolic Acidosis and Alkali Therapy on Linear Growth in Children with Chronic Kidney Disease: What Is the Current Evidence?Kidney360 · 2022Article
- Longitudinal Associations between Low Serum Bicarbonate and Linear Growth in Children with CKD.Kidney360 · 2022Article
- Effectiveness of growth hormone on growth and final height in paediatric chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2022Article
- Patterns of recombinant growth hormone therapy use and growth responses among children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Ultrasound-Based Renal Parenchymal Area and Kidney Function Decline in Infants With Congenital Anomalies of the Kidney and Urinary Tract.Seminars in nephrology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
objectivesTo compare the health-related quality of life (HRQoL) of children with chronic kidney disease (CKD) and short stature (SS) with that of children with CKD and normal height (NH), to evaluate the impact of catch-up growth and growth hormone (GH) use on HRQoL, and to describe the concordance of perceptions of HRQoL between children with SS and NH and their parents. STUDY
designFour hundred eighty-three children and/or parents enrolled in the multicenter Chronic Kidney Disease in Children study who had completed the Pediatric Quality of Life Inventory (Version 4.0) on at least 2 Chronic Kidney Disease in Children study visits composed this substudy population. Participants were dichotomized into NH or SS groups. The demographic characteristics that varied at baseline (sex, glomerular filtration rate, and parent education) were controlled for in the main analysis evaluating the impact of catch-up growth and use of GH on HRQoL.
resultsMultivariate modeling (controlling for confounding variables) revealed a significant association between both catch-up growth and GH use on parent-proxy reports of child physical functioning (P < .05) and social functioning (P < .05). Older children with CKD (15-17 years old) had significantly higher ratings than their parents on the Pediatric Quality of Life Inventory Physical, Emotional, Social, and School Functioning scales compared with younger children (8-14 years old).
conclusionThe finding that height gains and GH use are associated with increases in physical and social functioning by parent report provides additional support for interventions to improve height in children with CKD. The importance of evaluating both the parent and child perceptions of HRQoL is supported by our results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.