ArticleBMC evolutionary biology2013
Evolution of MHC class I genes in the endangered loggerhead sea turtle (Caretta caretta) revealed by 454 amplicon sequencing.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Warming and Change in Ocean Productivity Alter Phenology of an Expanding Loggerhead Population in Cabo Verde.Animals : an open access journal from MDPI · 2026Article
- Major Histocompatibility Complex Immunogenetic Diversity Differs Substantially Across Sea Turtle Species and Genomic Regions.Genome biology and evolution · 2026Article
- Moderate Genetic Diversity of MHC Genes in an Isolated Small Population of Black-and-White Snub-Nosed Monkeys (Animals : an open access journal from MDPI · 2024Article
- Adaptive evolution of major histocompatibility complex class I immune genes and disease associations in coastal juvenile sea turtles.Royal Society open science · 2022Article
- Genetic diversity of major histocompatibility complex class I genes in Zootoca vivipara.Bioscience reports · 2020Article
- Major histocompatibility complex class I diversity limits the repertoire of T cell receptors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- High polymorphism in MHC-DRB genes in golden snub-nosed monkeys reveals balancing selection in small, isolated populations.BMC evolutionary biology · 2018Article
- The evolution of the major histocompatibility complex in upstream versus downstream river populations of the longnose dace.Ecology and evolution · 2017Article
- Population genomics of an endemic Mediterranean fish: differentiation by fine scale dispersal and adaptation.Scientific reports · 2017Article
- Molecular characterization of MHC class IIB genes of sympatric Neotropical cichlids.BMC genetics · 2017Article
- Microsatellite and major histocompatibility complex variation in an endangered rattlesnake, the Eastern Massasauga (Sistrurus catenatus).Ecology and evolution · 2016Article
- New data from basal Australian songbird lineages show that complex structure of MHC class II β genes has early evolutionary origins within passerines.BMC evolutionary biology · 2016Article
- Changes in variation at the MHC class II DQA locus during the final demise of the woolly mammoth.Scientific reports · 2016Article
- Evaluating the adaptive potential of the European eel: is the immunogenetic status recovering?PeerJ · 2016Article
- Variation in positively selected major histocompatibility complex class I loci in rufous-collared sparrows (Zonotrichia capensis).Immunogenetics · 2014Article
- Extraordinary MHC class II B diversity in a non-passerine, wild bird: the Eurasian Coot Fulica atra (Aves: Rallidae).Ecology and evolution · 2014Article
- Evolution of MHC class I in the order Crocodylia.Immunogenetics · 2014Article
- Living on the edge: how philopatry maintains adaptive potential.Proceedings. Biological sciences · 2013Article
- Mate choice in sticklebacks reveals that immunogenes can drive ecological speciation.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn evolutionary and conservation biology, parasitism is often highlighted as a major selective pressure. To fight against parasites and pathogens, genetic diversity of the immune genes of the major histocompatibility complex (MHC) are particularly important. However, the extensive degree of polymorphism observed in these genes makes it difficult to conduct thorough population screenings.
methodsWe utilized a genotyping protocol that uses 454 amplicon sequencing to characterize the MHC class I in the endangered loggerhead sea turtle (Caretta caretta) and to investigate their evolution at multiple relevant levels of organization.
resultsMHC class I genes revealed signatures of trans-species polymorphism across several reptile species. In the studied loggerhead turtle individuals, it results in the maintenance of two ancient allelic lineages. We also found that individuals carrying an intermediate number of MHC class I alleles are larger than those with either a low or high number of alleles.
conclusionsMultiple modes of evolution seem to maintain MHC diversity in the loggerhead turtles, with relatively high polymorphism for an endangered species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.