ArticleCancer cell international2013
Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML.
Article in Cancer cell international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Deubiquitinases in hematological malignancies.Biomarker research · 2021Review
- A20 Inhibits Intraocular Inflammation in Mice by Regulating the Function of CD4+T Cells and RPE Cells.Frontiers in immunology · 2020Article
- Alteration of gene expression profile in CD3ImmunoTargets and therapy · 2018Article
- A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models.Frontiers in immunology · 2018Review
- lncRNA co-expression network model for the prognostic analysis of acute myeloid leukemia.International journal of molecular medicine · 2017Article
- The Paracaspase MALT1.Biochimie · 2016Review
- Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia.Cancer cell international · 2015Article
- Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia.European journal of medical research · 2014Article
- Changes of T-lymphocyte subpopulation and differential expression pattern of the T-bet and GATA-3 genes in diffuse large B-cell lymphoma patients after chemotherapy.Cancer cell international · 2014Article
- Alternative expression pattern of MALT1-A20-NF-κB in patients with rheumatoid arthritis.Journal of immunology research · 2014Article
- Abnormal expression of A20 and its regulated genes in peripheral blood from patients with lymphomas.Cancer cell international · 2014Article
- The TCR γδ repertoire and relative gene expression characteristics of T-ALL cases with biclonal malignant Vδ1 and Vδ2 T cells.DNA and cell biology · 2014Article
- The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies.Journal of hematology & oncology · 2013Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-κB and MALT1-V1 gene expression levels in CD3+ T cells sorted from the peripheral blood of patients with AML were analyzed by real-time PCR. A significantly lower MALT1 and A20 expression level was found in T cells from patients with AML compared with healthy controls (p = 0.045, p < 0.0001); however, the expression level of MALT1-V1 (variant 1) was significantly higher in the AML group than in the healthy control group (p = 0.006), and the expression level of NF-κB was increased in the AML group. In conclusion, the characteristics of the expression pattern of MALT1-A20-NF-κB and the distribution of MALT1 variants in T cells from AML were first characterized. Overall, low TCR-CD3 signaling is related to low MALT1 expression, which may related to T cell immunodeficiency, while the up-regulation of MALT1-V1 may play a role in overcoming the T cell activity by downregulating A20 in patients with AML, which may be related to a specific response to AML-associated antigens.
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Registered trials
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