ArticleNorth American journal of medical sciences2013
Chlamydophila pneumoniae infection and cardiovascular disease.
Article in North American journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Chlamydia pneumoniae-associated pleuropericarditis: a case report and systematic review of the literature.BMC pulmonary medicine · 2021Pooled it
- Chlamydia pneumoniae-Mediated Inflammation in Atherosclerosis: A Meta-Analysis.Mediators of inflammation · 2015Pooled it
- Chlamydia pneumoniae Seropositivity is Associated with Cardiovascular Events in the General Population: The Nagahama Study.Journal of atherosclerosis and thrombosis · 2026Article
- Increased Risk to Develop Hypertension and Carotid Plaques in Patients with Long-LastingJournal of clinical medicine · 2022Article
- Review
- Oxidative Stress and Inflammation in SARS-CoV-2- andBiomedicines · 2021Review
- Presence of bacterial DNA in thrombotic material of patients with myocardial infarction.Scientific reports · 2020Article
- Bacterial infections are associated with cardiovascular disease in Iran: a meta-analysis.Archives of medical science : AMS · 2019Article
- Review
- Review
- Updating the epidemiological transition model.Epidemiology and infection · 2018Article
- Atypical Pneumonia: Updates on Legionella, Chlamydophila, and Mycoplasma Pneumonia.Clinics in chest medicine · 2017Review
- Signaling events in pathogen-induced macrophage foam cell formation.Pathogens and disease · 2016Article
- Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- Article
- Association of Chlamydia pneumoniae Infection With Atherosclerotic Plaque Formation.Global journal of health science · 2015Article
- Article
- Biomarkers Related to Carotid Intima-Media Thickness and Plaques in Long-Term Survivors of Ischemic Stroke.Translational stroke research · 2015Article
- A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice.Cellular immunology · 2015Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis is a multifactorial vascular inflammatory process; however, the inciting cause for inflammation remains unclear. Two decades ago, Chlamydophila pneumoniae (formerly Chlamydia pneumoniae) infection was proposed as a putative etiologic agent. We performed a PubMed search using the keywords Chlamydia and atherosclerosis in a Boolean query to identify published studies on C. pneumoniae and its role in atherogenesis, and to understand research interest in this topic. We found 1,652 published articles on this topic between 1991 and 2011. We analyzed relevant published studies and found various serological, molecular, and animal modeling studies in the early period. Encouraged by positive results from these studies, more than a dozen antibiotic clinical-trials were subsequently conducted, which did not find clinical benefits of anti-Chlamydophila drug therapy. While many researchers believe that the organism is still important, negative clinical trials had a similar impact on overall research interest. With many novel mechanisms identified for atherogenesis, there is a need for newer paradigms in Chlamydophila-atherosclerosis research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.