ArticleJournal of developmental origins of health and disease2012
Early cohort mortality predicts the rate of aging in the cohort: a historical analysis.
Article in Journal of developmental origins of health and disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Article
- Early-life physical performance predicts the aging and death of elite athletes.Science advances · 2023Article
- Editorial: Health related quality of life inequalities.Frontiers in public health · 2023Article
- Population-level impact of adverse early life conditions on adult healthy life expectancy in low- and middle-income countries.Population studies · 2022Article
- Recent trends and increasing differences in life expectancy present opportunities for multidisciplinary research on aging.Nature aging · 2021Article
- Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.Aging cell · 2020Article
- Are We Approaching a Biological Limit to Human Longevity?The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- THE EXPOSOME IN HUMAN EVOLUTION: FROM DUST TO DIESEL.The Quarterly review of biology · 2019Article
- The Alzheimer's Disease Exposome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Male mortality rates mirror mortality rates of older females.Scientific reports · 2019Article
- Article
- Discrete Barker Frailty and Warped Mortality Dynamics at Older Ages.Demography · 2017Article
- Statin, testosterone and phosphodiesterase 5-inhibitor treatments and age related mortality in diabetes.World journal of diabetes · 2017Article
- Food availability affects adult survival trajectories depending on early developmental conditions.Proceedings. Biological sciences · 2017Article
- Sex-Based Differences in the Determinants of Old Age Life Expectancy: The Influence of Perimenopause.Biodemography and social biology · 2017Article
- Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Are We Reaching the Limits ofFrontiers in physiology · 2017Review
- Early-life disease exposure and associations with adult survival, cause of death, and reproductive success in preindustrial humans.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Constant molecular aging rates vs. the exponential acceleration of mortality.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.Biogerontology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Early environmental influences on later-life health and mortality are well recognized in the doubling of life expectancy since 1800. To further define these relationships, we analyzed the associations between early-life mortality and both the estimated mortality level at age 40 and the exponential acceleration in mortality rates with age characterized by the Gompertz model. Using mortality data from 630 cohorts born throughout the 19th and early 20th century in nine European countries, we developed a multilevel model that accounts for cohort and period effects in later-life mortality. We show that early-life mortality, which is linked to exposure to infection and poor nutrition, predicts both the estimated cohort mortality level at age 40 and the subsequent Gompertz rate of mortality acceleration during aging. After controlling for effects of country and period, the model accounts for the majority of variance in the Gompertz parameters (about 90% of variation in the estimated level of mortality at age 40 and about 78% of variation in the Gompertz slope). The gains in cohort survival to older ages are entirely due to large declines in adult mortality level, because the rates of mortality acceleration at older ages became faster. These findings apply to cohorts born in both the 19th century and the early 20th century. This analysis defines new links in the developmental origins of adult health and disease in which effects of early-life circumstances, such as exposure to infections or poor nutrition, persist into mid-adulthood and remain evident in the cohort mortality rates from ages 40 to 90.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.