ArticleInternational journal of preventive medicine2013
Preventive and curative effects of ginger extract against histopathologic changes of gentamicin-induced tubular toxicity in rats.
Article in International journal of preventive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 77 citations in OpenAlex.
- Article
- Network pharmacology, molecular docking, and dynamics analyses to predict the antiviral activity of ginger constituents against coronavirus infection.Scientific reports · 2024Article
- Protective effects of plant-derived natural products on renal complications.Journal of cellular physiology · 2019Review
- Ginger extract attenuates ethanol-induced pulmonary histological changes and oxidative stress in rats.Journal of biomedical research · 2017Article
- Traditional uses of medicinal plants to prevent and treat diabetes; an updated review of ethnobotanical studies in Iran.Journal of nephropathology · 2017Review
- Twisting electrospun nanofiber fine strips into functional sutures for sustained co-delivery of gentamicin and silver.Nanomedicine : nanotechnology, biology, and medicine · 2017Article
- Evaluating the efficacy of mixture ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Article
- The protective effect of hydro-alcoholic extract of mangrove (Journal of nephropathology · 2016Article
- Biochemical effects of oleuropein in gentamicin-induced nephrotoxicity in rats.ARYA atherosclerosis · 2016Article
- Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences.Jundishapur journal of microbiology · 2015Review
- On the Occasion of World Cancer Day 2015; the Possibility of Cancer Prevention or Treatment with Antioxidants: The Ongoing Cancer Prevention Researches.International journal of preventive medicine · 2015Review
- Morphological methods to evaluate protective agents against aminoglycoside-induced nephrotoxicity.Journal of renal injury prevention · 2015Article
- Pomegranate Flower Extract does not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats.International journal of preventive medicine · 2014Article
- New concepts in nutraceuticals as alternative for pharmaceuticals.International journal of preventive medicine · 2014Review
- Anethum graveolens and hyperlipidemia: A randomized clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- The Ameliorative Effect of Zingiber officinale in Diabetic Nephropathy.Iranian Red Crescent medical journal · 2014Article
- Teucrium polium: Liver and kidney effects.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Gingerol fraction from Zingiber officinale protects against gentamicin-induced nephrotoxicity.Antimicrobial agents and chemotherapy · 2014Article
- Comment on: Protective Role of Recombinant Human Erythropoietin in Kidney and Lung Injury Following Renal Bilateral Ischemia-reperfusion in Rat Model.International journal of preventive medicine · 2013Article
- Oxidative stress and aging prevention.International journal of preventive medicine · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGentamicin (GM) is a commonly used aminoglycoside, however, renal toxicity has limited its usage. This study was designed to evaluate the curative and protective effects of Zingiber officinale (ginger) against gentamicin tubular toxicity in rats. The phenolic and flavonoid components and antioxidant activity of ginger were also evaluated.
methodsIn a preclinical study, 50 male Wistar rats were designated into 5 groups of 10 and treated as follows: Group I: vehicle. Group II: 200 mg/kg/d of ginger for 3 days then, GM (80 mg/kg) for 7 days. Group III: 200 mg/kg ginger orally for 3 days, then ginger plus GM for 7 days. Group IV: GM for 7 days. Group V: GM for 10 days. Group VI: GM for 7 days, then 200 mg/kg ginger orally for 10 days. At the end of the study, the animals were sacrificed and their kidneys were histologically evaluated.
resultsGinger could prevent degeneration of the renal cells and reduce the severity of tubular damage caused by gentamicin. However, it could not regenerate the GM degeneration.
conclusionsThe results indicate that ginger is effective as a prophylaxis agent, but has not curative effect.
Indexed as
Identifiers
23626888PMC3634170W1494799814What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.